Dietary marine-derived long-chain monounsaturated fatty acids and cardiovascular disease risk: a mini review

Lipids in Health and Disease

Review

Alan T. Remaley¹  Beatrice Emma-Okon¹  Zhi-Hong Yang² 

[1] Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 20892-1666, Bethesda, MD, USA;Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 20892-1666, Bethesda, MD, USA;Central Research Laboratory, Tokyo Innovation Center, Nippon Suisan Kaisha, 32-3 Nanakuni 1 Chome Hachioji, 192-0991, Tokyo, Japan;

关键词: Long-chain monounsaturated fatty acids;    Cardiovascular disease;    Atherosclerosis;    Peroxisome proliferator-activated receptor signaling pathway;    Inflammation;   

DOI  :  10.1186/s12944-016-0366-5

 received in 2016-09-18, accepted in 2016-11-09,  发布年份 2016

来源: Springer

【 摘 要 】

Regular fish/fish oil consumption is widely recommended for protection against cardiovascular diseases (CVD). Fish and other marine life are rich sources of the cardioprotective long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (C20:5 n-3; EPA) and docosahexaenoic acid (C22:6 n-3; DHA). The lipid content and fatty acid profile of fish, however, vary greatly among different fish species. In addition to n-3 PUFA, certain fish, such as saury, pollock, and herring, also contain high levels of long-chain monounsaturated fatty acids (LCMUFA), with aliphatic tails longer than 18 C atoms (i.e., C20:1 and C22:1 isomers). Compared with well-studied n-3 PUFA, limited information, however, is available on the health benefits of marine-derived LCMUFA, particularly in regard to CVD. Our objective in this review is to summarize the current knowledge and provide perspective on the potential therapeutic value of dietary LCMUFA-rich marine oil for improving CVD risk factors. We will also review the possible mechanisms of LCMUFA action on target tissues. Finally, we describe the epidemiologic data and small-scaled clinical studies that have been done on marine oils enriched in LCMUFA. Although there are still many unanswered questions about LCMUFA, this appears to be promising new area of research that may lead to new insights into the health benefits of a different component of fish oils besides n-3 PUFA.

【 授权许可】

CC BY   
© The Author(s). 2016