Fructose in obesity and cognitive decline: is it the fructose or the excess energy?

Nutrition Journal

Letter to the Editor

Vanessa Ha¹  Laura Chiavaroli²  Cyril WC Kendall³  Russell J de Souza⁴  John L Sievenpiper⁵ 

[1] Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada;Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada;Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada;Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada;Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada;Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada;Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada;Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, HamiltonON, Canada;Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada;

关键词: Dietary fructose;    Cognitive decline;    Obesity;    Energy;   

DOI  :  10.1186/1475-2891-13-27

 received in 2014-02-06, accepted in 2014-02-24,  发布年份 2014

来源: Springer

【 摘 要 】

We read with interest the review by Lakhan and Kirchgessner, proposing that high fructose intake promotes obesity, metabolic syndrome, diabetes, and cognitive decline. Their focus on the role of fructose seems premature due to confounding from energy and the heavy reliance on low quality evidence from animal models. There is a lack of high quality evidence directly assessing the role of fructose in cognitive decline. Although one cannot exclude the possibility of a link, it remains an unconfirmed hypothesis.

【 授权许可】

Unknown   
© Chiavaroli et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.