Fructose in obesity and cognitive decline: is it the fructose or the excess energy?

Nutrition Journal

John L Sievenpiper⁴  Cyril WC Kendall²  Russell J de Souza¹  Vanessa Ha⁵  Laura Chiavaroli³ 

[1] Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada;College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada;Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada;Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital, Toronto, ON, Canada

关键词: Energy;    Obesity;    Cognitive decline;    Dietary fructose;   

Others  :  801641
DOI  :  10.1186/1475-2891-13-27

 received in 2014-02-06, accepted in 2014-02-24,  发布年份 2014

【 摘 要 】

We read with interest the review by Lakhan and Kirchgessner, proposing that high fructose intake promotes obesity, metabolic syndrome, diabetes, and cognitive decline. Their focus on the role of fructose seems premature due to confounding from energy and the heavy reliance on low quality evidence from animal models. There is a lack of high quality evidence directly assessing the role of fructose in cognitive decline. Although one cannot exclude the possibility of a link, it remains an unconfirmed hypothesis.

【 授权许可】

   
2014 Chiavaroli et al.; licensee BioMed Central Ltd.

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