Low fatness, reduced fat intake and adequate plasmatic concentrations of LDL-cholesterol are associated with high bone mineral density in women: a cross-sectional study with control group

Lipids in Health and Disease

Research

Lígia A Martini¹  Karin S Sarkis²  Vera L Szejnfeld³  Marcelo M Pinheiro⁴ 

[1] Nutrition Department, School of Public Health, Sao Paulo University, Av. Dr. Arnaldo, 715, CEP-01246-904, São Paulo - SP, Brazil;Nutrition Department, School of Public Health, Sao Paulo University, Av. Dr. Arnaldo, 715, CEP-01246-904, São Paulo-SP, Brazil;Rheumatology Division, Universidade Federal de São Paulo/Escola Paulista de Medicina (Unifesp/EPM), Av Dr Altino Arantes, 669, apto 105, Vila Clementino, CEP 04042-033, São Paulo-SP, Brazil;Rheumatology Division, Universidade Federal de São Paulo/Escola Paulista de Medicina (Unifesp/EPM), Av Dr Altino Arantes, 669, apto 105, Vila Clementino, CEP 04042-033, São Paulo-SP, Brazil;Rheumatology Division, Universidade Federal de São Paulo/Escola Paulista de Medicina (Unifesp/EPM), Rua Pedro de Toledo, 650-2° Andar-Vila Clementino, Disciplina de Reumatologia, CEP 04039-002, São Paulo-SP, Brazil;

关键词: Bone mineral density;    Body composition;    Lipid metabolism;    Diet;    Mineral metabolism;    Women;   

DOI  :  10.1186/1476-511X-11-37

 received in 2011-12-27, accepted in 2012-03-12,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundSeveral parameters are associated with high bone mineral density (BMD), such as overweight, black background, intense physical activity (PA), greater calcium intake and some medications. The objectives are to evaluate the prevalence and the main aspects associated with high BMD in healthy women.MethodsAfter reviewing the database of approximately 21,500 BMD scans performed in the metropolitan area of São Paulo, Brazil, from June 2005 to October 2010, high BMD (over 1400 g/cm2 at lumbar spine and/or above 1200 g/cm2 at femoral neck) was found in 421 exams. Exclusion criteria were age below 30 or above 60 years, black ethnicity, pregnant or obese women, disease and/or medications known to interfere with bone metabolism. A total of 40 women with high BMD were included and matched with 40 healthy women with normal BMD, paired to weight, age, skin color and menopausal status. Medical history, food intake and PA were assessed through validated questionnaires. Body composition was evaluated through a GE-Lunar DPX MD + bone densitometer. Radiography of the thoracic and lumbar spine was carried out to exclude degenerative alterations or fractures. Biochemical parameters included both lipid and hormonal profiles, along with mineral and bone metabolism. Statistical analysis included parametric and nonparametric tests and linear regression models. P < 0.05 was considered significant.ResultsThe mean age was 50.9 (8.3) years. There was no significant difference between groups in relation to PA, smoking, intake of calcium and vitamin D, as well as laboratory tests, except serum C-telopeptide of type I collagen (s-CTX), which was lower in the high BMD group (p = 0.04). In the final model of multivariate regression, a lower fat intake and body fatness as well a better profile of LDL-cholesterol predicted almost 35% of high BMD in women. (adjusted R2 = 0.347; p < 0.001). In addition, greater amounts of lean mass and higher IGF-1 serum concentrations played a protective role, regardless age and weight.ConclusionOur results demonstrate the potential deleterious effect of lipid metabolism-related components, including fat intake and body fatness and worse lipid profile, on bone mass and metabolism in healthy women.

【 授权许可】

Unknown   
© Sarkis et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.