Hyperammonemia decreases body fat content in rat

FEBS Letters

Wallace, R.¹  Felipo, V.¹  Miñana, M.D.¹  Grisolía, S.¹ 

[1] Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado de CSIC, Amadeo de Saboya, 4, 46010 Valencia, Spain

关键词: Hyperammonemia;    Body composition;    Lipid metabolism;    Carnitine;    Acetyl-CoA;    (Ketone bodies);   

DOI  :  10.1016/0014-5793(89)80636-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have developed an animal model of hyperammonemia consisting of feeding rats a diet containing 20% (w/w) ammonium acetate. Ingestion of this diet markedly affects carcass composition, with a 46% reduction in lipid content. The ammonium diet alters levels of several key compounds involved in lipid metabolism. Long-chain acylcarnitine is increased in liver by approx. 60% while free carnitine and acetylcarnitine are unaffected. The hepatic content of acetyl-CoA increases by approx. 50%. The level of ketone bodies in blood increases by 32% but remains unchanged in liver. Our data indicate that hyperammonemia alters lipid metabolism and results in a significant decrease in body lipid content.

【 授权许可】

Unknown