Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women

1st Annual Applied Science and Engineering Conference

工业技术;自然科学

Sari, D.K.^1 ; Tala, Z.Z.^1 ; Lestari, Sri^2 ; Hutagalung, S.V.^3 ; Ganie, R.A.^4

Nutrition Department, Faculty of Medicine, University of Sumatera Utara, Jl. dr. Mansur Kampus USU, Medan

20155, Indonesia^1

Public Health Department, Faculty of Medicine, University of Sumatera Utara, Jl. dr. Mansur Kampus USU, Medan

20155, Indonesia^2

Parasitology Department, Faculty of Medicine, University of Sumatera Utara, Jl. dr. Mansur Kampus USU, Medan

20155, Indonesia^3

Clinical Pathology Department, Faculty of Medicine, University of Sumatera Utara, Jl. dr. Mansur Kampus USU, Medan

20155, Indonesia^4

关键词: Adipocytes;    Body mass index;    Body weight;    Bone mineral density;    Half lives;    Health parameters;    Observational study;    Vitamin D-binding proteins;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/180/1/012281/pdf
DOI  :  10.1088/1757-899X/180/1/012281

来源: IOP

【 摘 要 】

Background: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D-binding protein (DBP). However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not associate with other bone health parameters. Objective:We sought to determine whether there is association between 25(OH)D 1) with bone health parameter differ by body weight; 2) Body mass index and BMD. Design: We conducted a cross-sectional observational study of 132 women aged 20-50 years in North Sumatera, Indonesia. Results: Serum total 25(OH)D was no different in normal, overweight, and obese women subjects (15.24.9 ng/mL). There was 77.3% categorized in deficiency and insufficiency (22.7%). There was no association among bone health parameters and body weight, but there is an association between BMD and body weight (p