Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol

BMC Cardiovascular Disorders

Study Protocol

Marianne Frederiksen¹  Rasmus Huan Olsen¹  Eva Prescott¹  Lene Rørholm Pedersen¹  Ahmad Sajadieh¹  Elizaveta Chabanova²  Steen Bendix Haugaard³  Arne Astrup⁴  Jens Juul Holst⁵  Rosemary Walzem⁶  Ulrik Wisløff⁷  John W Newman⁸  Philip Hasbak⁹  Andreas Kjær⁹ 

[1] Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark;Department of Diagnostic Radiology, University Hospital of Herlev, Copenhagen, Denmark;Department of Internal Medicine, Amager University Hospital, Copenhagen, Denmark;Clinical Research Centre, Hvidovre University Hospital, Copenhagen, Denmark;Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark;Faculty of Health and Medical Sciences, Department of Biomedical Sciences, Endocrinology Research Section, University of Copenhagen, Copenhagen, Denmark;Faculty of Nutrition, Texas A&M University, College Station, TX, USA;K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway;Obesity and Metabolism Research Unit, USDA-ARS-Western Human Nutrition Research Center, Davis, CA, USA;Rigshospitalet, Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen, Denmark;

关键词: Coronary artery disease;    Secondary prevention;    Rehabilitation;    Exercise;    Overweight;    Obesity;    Weight loss;    Life style changes;   

DOI  :  10.1186/1471-2261-13-106

 received in 2013-10-18, accepted in 2013-11-11,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundCoronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweight and 31% are obese. Physical inactivity and overweight are major risk factors in CAD, thus central strategies in secondary prevention are increased physical activity and weight loss.Methods/DesignIn a randomized controlled trial 70 participants with stable CAD, age 45–75, body mass index 28–40 kg/m2 and no diabetes are randomized (1:1) to 12 weeks of intensive exercise or weight loss both succeeded by a 40-week follow-up. The exercise protocol consist of supervised aerobic interval training (AIT) at 85-90% of VO2peak 3 times weekly for 12 weeks followed by supervised AIT twice weekly for 40 weeks. In the weight loss arm dieticians instruct the participants in a low energy diet (800–1000 kcal/day) for 12 weeks, followed by 40 weeks of weight maintenance combined with supervised AIT twice weekly. The primary endpoint of the study is change in coronary flow reserve after the first 12 weeks’ intervention. Secondary endpoints include cardiovascular, metabolic, inflammatory and anthropometric measures.DiscussionThe study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT. Additionally, it will provide new insight in mechanisms behind the benefits of exercise and weight loss. We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD.Trial registrationClinicalTrials.gov: NCT01724567

【 授权许可】

CC BY   
© Pedersen et al.; licensee BioMed Central Ltd. 2013