Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol

BMC Cardiovascular Disorders

Eva Prescott⁶  Steen Bendix Haugaard¹  Ahmad Sajadieh⁶  Ulrik Wisløff⁷  Rosemary Walzem²  John W Newman⁴  Andreas Kjær⁹  Jens Juul Holst⁸  Philip Hasbak⁹  Elizaveta Chabanova⁵  Arne Astrup³  Marianne Frederiksen⁶  Rasmus Huan Olsen⁶  Lene Rørholm Pedersen⁶ 

[1] Department of Internal Medicine, Amager University Hospital, Copenhagen, Denmark;Faculty of Nutrition, Texas A&M University, College Station, TX, USA;Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark;Obesity and Metabolism Research Unit, USDA-ARS-Western Human Nutrition Research Center, Davis CA, USA;Department of Diagnostic Radiology, University Hospital of Herlev, Copenhagen, Denmark;Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark;K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway;Faculty of Health and Medical Sciences, Department of Biomedical Sciences, Endocrinology Research Section, University of Copenhagen, Copenhagen, Denmark;Rigshospitalet, Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen, Denmark

关键词: Life style changes;    Weight loss;    Obesity;    Overweight;    Exercise;    Rehabilitation;    Secondary prevention;    Coronary artery disease;   

Others  :  855959
DOI  :  10.1186/1471-2261-13-106

 received in 2013-10-18, accepted in 2013-11-11,  发布年份 2013

【 摘 要 】

Background

Coronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweight and 31% are obese. Physical inactivity and overweight are major risk factors in CAD, thus central strategies in secondary prevention are increased physical activity and weight loss.

Methods/Design

In a randomized controlled trial 70 participants with stable CAD, age 45–75, body mass index 28–40 kg/m² and no diabetes are randomized (1:1) to 12 weeks of intensive exercise or weight loss both succeeded by a 40-week follow-up. The exercise protocol consist of supervised aerobic interval training (AIT) at 85-90% of VO₂peak 3 times weekly for 12 weeks followed by supervised AIT twice weekly for 40 weeks. In the weight loss arm dieticians instruct the participants in a low energy diet (800–1000 kcal/day) for 12 weeks, followed by 40 weeks of weight maintenance combined with supervised AIT twice weekly. The primary endpoint of the study is change in coronary flow reserve after the first 12 weeks’ intervention. Secondary endpoints include cardiovascular, metabolic, inflammatory and anthropometric measures.

Discussion

The study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT. Additionally, it will provide new insight in mechanisms behind the benefits of exercise and weight loss. We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD.

Trial registration

ClinicalTrials.gov:NCT01724567

【 授权许可】

   
2013 Pedersen et al.; licensee BioMed Central Ltd.

【 图 表 】

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