Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study

Thrombosis Journal

Original Clinical Investigation

Siegfried Wieshammer¹  Dirk Müller¹  Andreas Jakob²  Felix Momm³  Jens Dreyhaupt⁴ 

[1] Department of Cardiology, Pulmonology and Critical Care Medicine, Offenburg Hospital, Weingartenstrasse 70, D-77654, Offenburg, Germany;Department of Medical Oncology, Offenburg Hospital, D-77654, Offenburg, Germany;Department of Radiation Oncology, Offenburg Hospital, D-77654, Offenburg, Germany;Institute of Epidemiology and Medical Biometry, University of Ulm, D-89075, Ulm, Germany;

关键词: Venous thromboembolism;    Pulmonary hypertension;    Cancer;    Heart disease;   

DOI  :  10.1186/s12959-016-0077-1

 received in 2015-05-26, accepted in 2016-01-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCancer patients are at increased risk for venous thromboembolism (VTE).ObjectiveThis monocenter cross-sectional study prospectively assessed the association between a history of ≥1 VTE episode and the presence of pulmonary hypertension (PH) among cancer patients presenting with pulmonary or cardiac symptoms.MethodsA consecutive series of 583 patients underwent a diagnostic work-up for heart and lung disease. PH was diagnosed if a patient’s peak systolic pressure gradient across the tricuspid valve was ≥35 mmHg, as measured by echocardiography. Using multiple logistic regression analysis, the association between VTE and PH was assessed, following adjustments for age, the presence of severe airway obstruction, atrial fibrillation and left heart diseases.ResultsThe prevalence values for PH (n = 90) and a history of VTE (n = 72) were 15.4 and 12.3 %, respectively. The median time interval between the first VTE episode and referral was 43 months. The odds of PH was higher in the subgroup with VTE (19/72; 26.4 %) than that without VTE (71/511; 13.9 %) in the unadjusted analysis [odds ratio (OR) 2.2, 95 % confidence interval (CI) 1.2, 4.0] and the adjusted model [OR 2.4, 95 % CI 1.2, 4.5]. The risk of PH did not depend on the time interval between VTE and referral. Older age and the presence of severe airway obstruction, atrial fibrillation, and left heart diseases were also associated with an increased odds of PH.ConclusionIn cancer patients presenting with cardiac or pulmonary symptoms, previous VTE is associated with an increased risk of persistent PH.

【 授权许可】

CC BY   
© Wieshammer et al. 2016