Daily egg consumption in hyperlipidemic adults - Effects on endothelial function and cardiovascular risk

Nutrition Journal

Research

Anjelica L Gonzalez-Simon¹  Suparna Dutta²  Valentine Njike³  Zubaida Faridi³  David L Katz⁴ 

[1] Department of Biomedical Engineering, Yale University, 55 Prospect St, 06511-6816, New Haven, CT, USA;Griffin Hospital, 130 Division Street, 06418, Derby, CT, USA;Yale-Griffin Prevention Research Center, 130 Division Street, 06418, Derby, CT, USA;Yale-Griffin Prevention Research Center, 130 Division Street, 06418, Derby, CT, USA;Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, 06510-3210, New Haven, CT, USA;

关键词: Cholesterol;    Endothelial Function;    Brachial Artery;    Dietary Cholesterol;    Flow Mediate Dilatation;   

DOI  :  10.1186/1475-2891-9-28

 received in 2009-10-16, accepted in 2010-07-02,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLimiting consumption of eggs, which are high in cholesterol, is generally recommended to reduce risk of cardiovascular disease. However, recent evidence suggests that dietary cholesterol has limited influence on serum cholesterol or cardiac risk.ObjectiveTo assess the effects of egg consumption on endothelial function and serum lipids in hyperlipidemic adults.MethodsRandomized, placebo-controlled crossover trial of 40 hyperlipidemic adults (24 women, 16 men; average age = 59.9 ± 9.6 years; weight = 76.3 ± 21.8 kilograms; total cholesterol = 244 ± 24 mg/dL). In the acute phase, participants were randomly assigned to one of the two sequences of a single dose of three medium hardboiled eggs and a sausage/cheese breakfast sandwich. In the sustained phase, participants were then randomly assigned to one of the two sequences of two medium hardboiled eggs and 1/2 cup of egg substitute daily for six weeks. Each treatment assignment was separated by a four-week washout period. Outcome measures of interest were endothelial function measured as flow mediated dilatation (FMD) and lipid panel.ResultsSingle dose egg consumption had no effects on endothelial function as compared to sausage/cheese (0.4 ± 1.9 vs. 0.4 ± 2.4%; p = 0.99). Daily consumption of egg substitute for 6 weeks significantly improved endothelial function as compared to egg (1.0 ± 1.2% vs. -0.1 ± 1.5%; p < 0.01) and lowered serum total cholesterol (-18 ± 18 vs. -5 ± 21 mg/dL; p < 0.01) and LDL (-14 ± 20 vs. -2 ± 19 mg/dL; p = 0.01). Study results (positive or negative) are expressed in terms of change relative to baseline.ConclusionsEgg consumption was found to be non-detrimental to endothelial function and serum lipids in hyperlipidemic adults, while egg substitute consumption was beneficial.

【 授权许可】

Unknown   
© Njike et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.