Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5–9 years – a prospective study

Environmental Health

Research

Gunnar Toft¹  Birgit Bjerre Høyer¹  Carsten Obel²  Jens Peter Bonde³  Cecilia Høst Ramlau-Hansen⁴  Victor Ogniev⁵  Agnieszka Hernik⁶  Lars Rylander⁷  Bo AG Jönsson⁷  Anna Rignell-Hydbom⁷  Christian H Lindh⁷  Henning Sloth Pedersen⁸ 

[1] Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Nørrebrogade 44, building 2c, 8000, Aarhus, Denmark;Department of General Practice, School of Public Health, Aarhus University, Bartholins Allé 2, 8000, Aarhus, Denmark;Department of Occupational and Environmental Medicine, Copenhagen University Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, NV, Denmark;Department of Public Health, Section for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus, Denmark;Department of Social Medicine and Organization of Public Health, Kharkiv National Medical University, 61022, Kharkiv, Ukraine;Department of Toxicology and Risk Assessment, National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791, Warsaw, Poland;Division of Occupational and Environmental Medicine, Lund University, S-221 85, Lund, Sweden;Primary Health Care Clinic, Postbox 570, DK-3900, Nuuk, Greenland;

关键词: Behaviour;    Child;    Child development;    Cohort study;    Motor development;    Perfluorooctanoate (PFOA);    Perfluorooctane sulfonate (PFOS);    Prenatal exposure, Delayed effects;   

DOI  :  10.1186/1476-069X-14-2

 received in 2014-08-08, accepted in 2014-12-17,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundIn animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5–9 years of age.MethodsMaternal sera from the INUENDO cohort (2002–2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses. Child motor development and behaviour at follow-up (2010–2012) were measured by the Developmental Coordination Disorder Questionnaire 2007 (DCDQ) and Strength and Difficulties Questionnaire (SDQ), respectively. Exposure-outcome associations were analysed by multiple logistic and linear regression analyses.ResultsIn the pooled analysis, odds ratio (OR) (95% confidence interval (CI)) for hyperactivity was 3.1 (1.3, 7.2) comparing children prenatally exposed to the highest PFOA tertile with those exposed to the lowest PFOA tertile. Comparing children in the highest PFOS tertile with those in the lowest PFOS tertile showed elevated but statistically non-significant OR of hyperactivity (OR (95% CI) 1.7 (0.9, 3.2)). In Greenland, elevated PFOS was associated with higher SDQ-total scores indicating more behavioural problems (β (95% CI) =1.0 (0.1, 2.0)) and elevated PFOA was associated with higher hyperactivity sub-scale scores indicating more hyperactive behaviour (β (95% CI) = 0.5 (0.1, 0.9)). Prenatal PFOS and PFOA exposures were not associated with motor difficulties.ConclusionsPrenatal exposure to PFOS and PFOA may have a small to moderate effect on children’s neuro-behavioural development, specifically in terms of hyperactive behaviour. The associations were strongest in Greenland where exposure contrast is largest.

【 授权许可】

CC BY   
© Høyer et al.; licensee BioMed Central. 2015