The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits

Environment International

Young Ah Lee¹  Bung-Nyun Kim²  Choong Ho Shin²  Johanna Inhyang Kim³  Youn-Hee Lim³  Yun-Chul Hong⁴  Kyung-Shin Lee⁵ 

[1] Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark;Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea;Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea;Division of Children and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea;Research Institue for Public Health, National Medical Center, Seoul, Republic of Korea;

关键词: Attention-deficit/hyperactivity disorder;    Child development;    Cohort study;    Critical period;    Pyrethroids;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Pyrethroid insecticides are commonly used in residential settings, and their use has increased rapidly. Although research has been scarce, they have been reported to be associated with impaired neurodevelopment. Moreover, susceptible exposure windows and the long-term effects of pyrethroids have not been investigated. We examined the association between pyrethroid exposure and attention-deficit/hyperactivity disorder (ADHD) symptoms over time, with exposure windows spanning from the prenatal period to school-age. Methods: Using 524 mother–child pairs, we measured urinary concentrations of 3-phenoxybenzoic acid (3-PBA), a major pyrethroid metabolite, and asked parents to fill-out the ADHD Rating Scale IV (ARS). We used Poisson regression to identify the susceptible periods of pyrethroid exposure, by correlating various 3-PBA exposure windows (prenatal, ages 2, 4, 6 and 8) with ADHD symptoms at ages 6 and 8. Results: Doubling of prenatal and age 2 3-PBA concentrations was associated with increased ADHD symptoms at age 6 (2.7% change, 95% confidence interval [CI]: 0.3, 5.2; 5.2% change [95% CI: 0.5, 10.2], respectively). The 3-PBA concentrations at age 4 and age 6 were linked with ADHD symptoms at age 8 (2.7% change [95% CI: 0.3, 5.3]; 3.3% change [95% CI: 0.2, 6.4], respectively). There were no clear sex-specific patterns in association. Discussion: Both prenatal and early-childhood exposure to 3-PBA were found to be associated with ADHD symptoms. Exposure during pregnancy, and at ages 2 to 6 were found to be susceptible periods for pyrethroid neurotoxicity at ages 6 and 8.

【 授权许可】

Unknown