Malaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast

Malaria Journal

Research

Chris Drakeley¹  Polycarp Mogeni²  Joseph Mwangangi²  Janet Midega²  Dora Mkabili²  Patricia Njuguna²  Joyce Mwongeli²  David Tiga Kangoye²  Christine Kerubo²  Pauline Akoo²  Abdisalan Noor²  Kevin Marsh³  Philip Bejon³ 

[1] Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK;Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research, P.O. Box 230, 80108, Kilifi, Kenya;Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research, P.O. Box 230, 80108, Kilifi, Kenya;Nuffield Department of Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, UK;

关键词: Malaria;    Hotspots;    Spatial scan statistic;    Antibodies;    Serology;    Asymptomatic parasitemia;    Transmission;    Targeted intervention;   

DOI  :  10.1186/s12936-016-1260-3

 received in 2015-12-18, accepted in 2016-03-31,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundTargeted malaria control interventions are expected to be cost-effective. Clinical, parasitological and serological markers of malaria transmission have been used to detect malaria transmission hotspots, but few studies have examined the relationship between the different potential markers in low transmission areas. The present study reports on the relationships between clinical, parasitological, serological and entomological markers of malaria transmission in an area of low transmission intensity in Coastal Kenya.MethodsLongitudinal data collected from 831 children aged 5–17 months, cross-sectional survey data from 800 older children and adults, and entomological survey data collected in Ganze on the Kenyan Coast were used in the present study. The spatial scan statistic test used to detect malaria transmission hotspots was based on incidence of clinical malaria episodes, prevalence of asymptomatic asexual parasites carriage detected by microscopy and polymerase chain reaction (PCR), seroprevalence of antibodies to two Plasmodium falciparum merozoite antigens (AMA1 and MSP1-19) and densities of Anopheles mosquitoes in CDC light-trap catches.ResultsThere was considerable overlapping of hotspots by these different markers, but only weak to moderate correlation between parasitological and serological markers. PCR prevalence and seroprevalence of antibodies to AMA1 or MSP1-19 appeared to be more sensitive markers of hotspots at very low transmission intensity.ConclusionThese findings may support the choice of either serology or PCR as markers in the detection of malaria transmission hotspots for targeted interventions.

【 授权许可】

CC BY   
© Kangoye et al. 2016