The effect of succinylcholine on malignant hyperthermia events in susceptible swine

BMC Anesthesiology

Research Article

Susanne Moegele¹  Frank Schuster¹  Stephan Johannsen¹  Norbert Roewer¹  Martin Anetseder²  Thomas Metterlein³ 

[1] Department of Anaesthesia and Critical Care, University of Wuerzburg, Oberduerrbacher Straße 6, D-97080, Wuerzburg, Germany;Department of Anaesthesia, Hospital Landshut-Achdorf, Landshut, Germany;Department of Anaesthesiology, University of Regensburg, Regensburg, Germany;

关键词: Malignant hyperthermia;    Succinylcholine;    Halothane;    Swine;   

DOI  :  10.1186/1471-2253-14-14

 received in 2013-10-25, accepted in 2014-03-05,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundWhile the impact of volatile anaesthetics to induce malignant hyperthermia (MH) is abundantly clear, the role of succinylcholine still remains controversial. To evaluate the influence of succinylcholine on porcine MH events, the authors investigated the hemodynamic and metabolic responses in MH susceptible (MHS) and non-susceptible (MHN) swine following either succinylcholine or halothane application alone or a combination of both substances.MethodsWith approval of the local animal care committee 27 MHS and 30 MHN pigs were anaesthetized and mechanically ventilated. Fiberoptic probes for continuous PCO2 measurement were inserted into the femoral vein and the triceps muscle. Group A received succinylcholine 4 mg/kg, group B incremental doses of halothane (0.5, 1.0 vol%) and group C succinylcholine and halothane simultaneously. Vital signs were recorded continuously.ResultsPrior to drug application measured values did not differ between MHS and MHN. While MHN pigs did not show relevant alterations, succinylcholine, halothane and the combination of both lead to significant hemodynamic and metabolic changes in MHS swine.ConclusionsHemodynamic and metabolic alterations following succinylcholine were similar to halothane in MHS pigs. The combination of both pharmacological agents potentiated the observed effects. According to these results succinylcholine acted as an independent and supportive factor during onset of an MH episode.

【 授权许可】

CC BY   
© Schuster et al.; licensee BioMed Central Ltd. 2014