Endocardial border delineation capability of a novel multimodal polymer-shelled contrast agent

Cardiovascular Ultrasound

Research

Gaio Paradossi¹  Greg Nowak²  Malin K Larsson³  Lars-Åke Brodin⁴  Birgitta Janerot Sjöberg⁵  Matilda Larsson⁶  Anna Bjällmark⁶  Kenneth Caidahl⁷ 

[1] Department of Chemical Sciences and Technologies, Università di Roma Tor Vergata, Rome, Italy;Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Alfred Nobels Allé 10, 141 52, Huddinge, Sweden;Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Alfred Nobels Allé 10, 141 52, Huddinge, Sweden;Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Alfred Nobels Allé 10, 141 52, Huddinge, Sweden;Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden;Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Alfred Nobels Allé 10, 141 52, Huddinge, Sweden;Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden;Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden;Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden;

关键词: Contrast agent;    Echocardiography;    Endocardial border delineation;    Microbubbles;    Polyvinyl alcohol;    Porcine;    Ultrasound;   

DOI  :  10.1186/1476-7120-12-24

 received in 2014-05-19, accepted in 2014-06-30,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundA novel polymer-shelled contrast agent (CA) with multimodal and target-specific potential was developed recently. To determine its ultrasonic diagnostic features, we evaluated the endocardial border delineation as visualized in a porcine model and the concomitant effect on physiological variables.MethodsThree doses of the novel polymer-shelled CA (1.5 ml, 3 ml, and 5 ml [5 × 108 microbubbles (MBs)/ml]) and the commercially available CA SonoVue (1.5 ml [2–5 × 108 MBs/ml]) were used. Visual evaluations of ultrasound images of the left ventricle were independently performed by three observers who graded each segment in a 6-segment model as either 0 = not visible, 1 = weakly visible, or 2 = visible. Moreover, the duration of clinically useful contrast enhancement and the left ventricular opacification were determined. During anesthesia, oxygen saturation, heart rate, and arterial pressure were sampled every minute and the effect of injection of CA on these physiological variables was evaluated.ResultsThe highest dose of the polymer-shelled CA gave results comparable to SonoVue. Thus, no significant difference in the overall segment score distribution (2-47-95 vs. 1-39-104), time for clinically sufficient contrast enhancement (20–40 s for both) and left ventricular overall opacification was found. In contrast, when comparing the endocardial border delineation capacity for different regions SonoVue showed significantly higher segment scores for base and mid, except for the mid region when injecting 1.5 ml of the polymer-shelled CA. Neither high nor low doses of the polymer-shelled CA significantly affected the investigated physiological variables.ConclusionsThis study demonstrated that the novel polymer-shelled CA can be used in contrast-enhanced diagnostic imaging without influence on major physiological variables.

【 授权许可】

CC BY   
© Larsson et al.; licensee BioMed Central Ltd. 2014