Determining the size of nanoparticles in the example of magnetic iron oxide core-shell systems

6th International Conference on Manufacturing Engineering and Process

工业技术;物理学

Jarzbski, MacIej^1 ; Kociski, Mikolaj^2 ; Bialopiotrowicz, Tomasz^1

Department of Physical Chemistry and Physicochemical Basis of Environmental Engineering, Institute of Environmental Engineering Off-Campus, Faculty of Law and Social Sciences in Stalowa Wola Catholic, University of Lublin, Kwiatkowskiego 3A, Stalowa Wola

37-450, Poland^1

Department of Physics, Poznan Life Science University, Wojska Polskiego 38/42, Pozna, Poland^2

关键词: Biomedical applications;    Contrast agent;    Fluorescent Correlation Spectroscopy;    Fluorescent dyes;    Magnetic iron oxides;    Nanoparticle sizes;    Nanoparticle tracking analysis;    Particles sizes;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/885/1/012007/pdf
DOI  :  10.1088/1742-6596/885/1/012007

学科分类：工业工程学

来源: IOP

【 摘 要 】

The size of nanoparticles is one of the most important factors for their possible applications. Various techniques for the nanoparticle size characterization are available. In this paper selected techniques will be considered base on the prepared core-shell magnetite nanoparticles. Magnetite is one of the most investigated and developed magnetic material. It shows interesting magnetic properties which can be used for biomedical applications, such as drug delivery, hypothermia and also as a contrast agent. To reduce the toxic effects of Fe3O4, magnetic core was covered by dextran and gelatin. Moreover, the shell was doped by fluorescent dye for confocal microscopy investigation. The main investigation focused on the methods for particles size determination of modified magnetite nanoparticles prepared with different techniques. The size distribution were obtained by nanoparticle tracking analysis, dynamic light scattering and transmission electron microscopy. Furthermore, fluorescent correlation spectroscopy (FCS) and confocal microscopy were used to compare the results for particle size determination of core-shell systems.