Diplotypes of CYP2C9 gene is associated with coronary artery disease in the Xinjiang Han population for women in China

Lipids in Health and Disease

Research

Qing Zhu¹  Yitong Ma¹  Fen Liu¹  Zhenyan Fu¹  Xiang Xie¹  Erdenbat Cha¹  Shuo Pan¹  Ding Huang¹ 

[1] Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Li Yu Shan South Road 137, 830054, Urumqi, China;

关键词: CYP2C9;    Single-nucleotide polymorphism;    Haplotype;    Diplotype;    Case–control study;   

DOI  :  10.1186/1476-511X-13-143

 received in 2014-04-29, accepted in 2014-08-12,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundCytochrome P450 (CYP) 2C9 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have the crucial role in the modulation of cardiovascular homeostasis. We sought to assess the association between the human CYP2C9 gene and coronary artery disease (CAD) in Xinjiang Han Population of China.Methods301 CAD patients and 220 control subjects were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP2C9 gene (rs4086116, rs2475376, rs1057910, and rs1934967) by a Real-Time PCR instrument. The datas were assessed for 3 groups: total, men, and women via diplotype-based case–control study.ResultsFor women, the distribution of genotypes, dominant model and alleles of SNP2 (rs2475376) showed significant difference between the CAD patients and control participants (p = 0.033, P = 0.010 and p = 0.038, respectively). The significant difference of the dominant model (CC vs CT + TT) was retained after adjustment for covariates in women (OR: 2.427, 95% confidence interval [CI]: 1.305-4.510, p = 0.005). The haplotype (C-T-A-C) and the diplotypes (CTAC/CTAC) in CYP2C9 gene were lower in CAD patients than in control subjects (p* = 0.0016, and p* = 0.036 respectively). The haplotype (C-C-A-T) was higher in the CAD patients than in the control subjects in women (p* = 0.016).ConclusionsCC genotype of rs2475376 and C-C-A-T haplotype in CYP2C9 may be a risk genetic marker of CAD in women. T allele of rs2475376, the haplotype (C-T-A-C) and the diplotype (CTAC/CTAC) could be protective genetic markers of CAD for women in Han population of China.

【 授权许可】

Unknown   
© Fu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.