Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Lipids in Health and Disease

Research

Masanori Abe¹  Shuzo Takayama¹  Ryuichi Kawamoto²  Tomo Kusunoki²  Tateaki Katoh³  Nobuyuki Ohtsuka³  Yasuharu Tabara⁴  Katsuhiko Kohara⁴  Tetsuro Miki⁴ 

[1] Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan;Geriatric Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;

关键词: Body Mass Index;    Insulin Resistance;    Positive Likelihood Ratio;    Overweight Subject;    Lipid Ratio;   

DOI  :  10.1186/1476-511X-9-138

 received in 2010-10-07, accepted in 2010-12-07,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe aim of the present study was to examine how lipid profiles are associated with insulin resistance in Japanese community-dwelling adults.MethodsThis cross-sectional study included 614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years. The study sample were 1,042 (74.8%) non-obese (BMI < 25.0 kg/m2) and 351 (25.2%) overweight (BMI ≥ 25 kg/m2) subjects. Insulin resistance was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. The areas under the curve (AUC) of the receiver operating characteristic curves (ROC) were used to compare the power of these serum markers.ResultsIn non-obese subjects, the best marker of insulin resistance was low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio of 0.74 (95% confidence interval (CI), 0.66-0.80). The HDL-C, triglyceride (TG)/HDL-C ratio, and non-HDL-C also discriminated insulin resistance, as the values for AUC were 0.31 (95% CI, 0.24-0.38), 0.69 (95% CI, 0.62-0.75) and 0.69 (95% CI, 0.62-0.75), respectively. In overweight subjects, the AUC for TG and TG/HDL-C ratio were 0.64 (0.58-0.71) and 0.64 (0.57-0.70), respectively. The optimal cut-off point to identifying insulin resistance for these markers yielded the following values: TG/HDL-C ratio of ≥1.50 and LDL-C/HDL-C ratio of ≥2.14 in non-obese subjects, and ≥2.20, ≥2.25 in overweight subjects. In non-obese subjects, the positive likelihood ratio was greatest for LDL-C/HDL-C ratio.ConclusionIn non-obese Japanese adults, LDL-C/HDL-C ratio may be the best reliable marker of insulin resistance.

【 授权许可】

CC BY   
© Kawamoto et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.