Osteoprotegerin in breast cancer: beyond bone remodeling

Molecular Cancer

Review

Linda Connelly¹  Stephanie Tsang Mui Chung¹  Michael Weichhaus² 

[1] Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 96720, Hilo, HI, USA;Division of Natural Science and Mathematics, Chaminade University of Honolulu, 3140 Waialae Avenue, 96816, Honolulu, HI, USA;

关键词: Osteoprotegerin;    Bone;    TNF-related apoptosis inducing ligand (TRAIL);    Apoptosis;    Angiogenesis;    Metastasis;   

DOI  :  10.1186/s12943-015-0390-5

 received in 2015-03-26, accepted in 2015-05-20,  发布年份 2015

来源: Springer

【 摘 要 】

Osteoprotegerin (OPG) is a secreted protein and member of the Tumor Necrosis Factor (TNF) Receptor superfamily. OPG has been well characterized as a regulator of bone metabolism which acts by blocking osteoclast maturation and preventing bone breakdown. Given this role, early studies on OPG in breast cancer focused on the administration of OPG in order to prevent the osteolysis observed with bone metastases. However OPG is also produced by the breast tumor cells themselves. Research focusing on OPG produced by breast tumor cells has revealed actions of OPG which promote tumor progression. In vitro studies into the role of OPG produced by breast tumor cells have demonstrated that OPG can block TNF-related apoptosis inducing ligand (TRAIL)-mediated apoptosis. Furthermore, in vivo studies show that OPG expression by breast tumors can promote tumor growth and metastasis. In addition it has been shown that OPG stimulates endothelial cell survival and tube formation thus it may indirectly promote breast tumor progression through impacting angiogenesis. This article will present a summary of the data concerning the tumor-promoting effects of OPG in breast cancer.

【 授权许可】

Unknown   
© Weichhaus et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.