PCIF1, the only methyltransferase of N6,2-O-dimethyladenosine

Cancer Cell International

Review

Xi Pu¹  Sihui Wu¹  Yuting Wu¹  Yiran Zhang¹  Min Xu²  Xu Wang³  Haowen Tang³  Shengqiao Fu³ 

[1] Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001, Zhenjiang, Jiangsu, China;Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001, Zhenjiang, Jiangsu, China;Digestive Disease Research Institute of Jiangsu University, 212001, Zhenjiang, Jiangsu, China;Department of Radiation Oncology, Institute of Oncology, Affiliated Hospital of Jiangsu University, 212001, Zhenjiang, Jiangsu, China;

关键词: PCIF1;    N6,2-O-dimethyladenosine;    Immunity;    PD-1;   

DOI  :  10.1186/s12935-023-03066-7

 received in 2023-05-03, accepted in 2023-09-14,  发布年份 2023

来源: Springer

【 摘 要 】

N6-methyladenosine(m6A), is the most abundant post-transcriptional modification of mRNA in biology. When the first nucleotide after the m7G cap is adenosine, it is methylated at the N6 position to form N6,2-O-dimethyladenosine (m6Am). m6Am is a reversible modification located at the first transcribed nucleotide, which is present in about 30% of cellular mRNAs, thus m6Am can have a significant impact on gene expression in the transcriptome. Phosphorylated CTD interaction factor 1(PCIF1), the unique and specific methyltransferase of m6Am, has been shown to affect mRNA stability, transcription, and translation. Several studies have shown that PCIF1 is clearly associated with tumor, viral, and endocrine diseases. Moreover, PCIF1 may be related to the tumor microenvironment, immune cell typing, and programmed cell death protein 1(PD-1) drug resistance. Here, we summarize the mechanism of PCIF1 involvement in mRNA modifications, and outline m6Am modifications and diseases in which PCIF1 is involved. We also summarized the role of PCIF1 in immune and immune checkpoint blockade(ICB) treatment, and predicted the possibility of PCIF1 as a biomarker and therapeutic target.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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Fig. 3