A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections

Malaria Journal

Case Report

Catriona McLean¹  Anna Rosanas-Urgell²  Peter Siba²  Henry Edoni²  Ivo Mueller³  Timothy ME Davis⁴  Laurens Manning⁴  Moses Laman⁵ 

[1] Department of Medicine, Faculty of Medicine Nursing and Health Sciences, Alfred Hospital, Prahran, Victoria, Australia;Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea;Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea;Infection and Immunity Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia;Centre de Recerca en Salut Internacional de Barcelona (CRESIB), Barcelona, Spain;School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, 6959, Fremantle, Western Australia, Australia;School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, 6959, Fremantle, Western Australia, Australia;Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea;

关键词: Plasmodium vivax;    Post mortem biopsy;    PCR;    Cerebral malaria;    Children;   

DOI  :  10.1186/1475-2875-11-107

 received in 2011-11-26, accepted in 2012-04-03,  发布年份 2012

来源: Springer

【 摘 要 】

Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria. Severely-ill Papua New Guinean children with mixed P. falciparum/P. vivax infections are more likely to develop cerebral malaria and die than those with P. falciparum alone, possibly reflecting P. vivax sequestration. Nested PCR was performed on post mortem brain tissue from three such children dying from cerebral malaria due to mixed-species infections. No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain.

【 授权许可】

Unknown   
© Manning et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.