A heavy legacy: offspring of malaria-infected mosquitoes show reduced disease resistance

Malaria Journal

Research

Kounbobr Roch Dabiré¹  Anna Cohuet²  Amélie Vantaux²  Thierry Lefèvre² 

[1] IRSS, 01 BP 171, Bobo Dioulasso, Burkina Faso;Centre Muraz, Bobo Dioulasso, Burkina Faso;UMR MIVEGEC (IRD 224 - CNRS 5290 - UM1 - UM2), BP 64501, 911 Avenue Agropolis, 34394, Montpellier Cedex 5, France;IRSS, 01 BP 171, Bobo Dioulasso, Burkina Faso;

关键词: Anopheles coluzzii;    Anopheles gambiae;    Plasmodium falciparum;    Maternal effects;    Malaria;   

DOI  :  10.1186/1475-2875-13-442

 received in 2014-09-02, accepted in 2014-11-05,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundTrans-generational effects of immune stimulation may have either adaptive (trans-generational immune priming) or non-adaptive (fitness costs) effects on offspring ability to fight pathogens.MethodsAnopheles coluzzii and its natural malaria parasite Plasmodium falciparum were used to test how maternal parasite infection affected offspring resistance to the same parasite species.ResultsDaughters of exposed mothers had similar qualitative resistance, as measured by their ability to prevent infection, relative to those of control mothers. However, maternal disease exposure altered offspring quantitative resistance, measured as the ability to limit parasite development, with mosquitoes of infected mothers suffering slightly increased parasite intensity compared to controls. In addition, quantitative resistance was minimal in offspring of highly infected mothers, and in offspring issued from eggs produced during the early infection phase.ConclusionsPlasmodium falciparum infection in An. coluzzii can have trans-generational costs, lowering quantitative resistance in offspring of infected mothers. Malaria-exposed mosquitoes might heavily invest in immune defences and thereby produce lower quality offspring that are poorly resistant.

【 授权许可】

CC BY   
© Vantaux et al.; licensee BioMed Central Ltd. 2014