期刊论文详细信息
Journal of Medical Case Reports
Memantine administration prevented chorea movement in Huntington’s disease: a case report
Case Report
Atsuko Ikegawa1  Itsuki Oda1  Susumu Kusunoki2  Yuko Yamagishi2  Yoshitaka Nagai2  Keisuke Yoshikawa2  Makito Hirano2  Makoto Samukawa2  Yoshiyuki Mitsui2  Kazumasa Saigoh3 
[1] Department of Clinical Genetics, Kindai University Hospital, Osakasayama, Japan;Department of Neurology, Faculty of Medicine, Kindai University, Osakasayama, Japan;Department of Neurology, Faculty of Medicine, Kindai University, Osakasayama, Japan;Department of Life Science, Faculty of Science, and Engineering, Kindai University, 377-2, Ohno-Higashi, 589-8511, Osakasayama, Osaka, Japan;Department of Clinical Genetics, Kindai University Hospital, Osakasayama, Japan;
关键词: Huntington’s disease;    SPECT;    Alzheimer’s disease;    Memantine;    Case report;   
DOI  :  10.1186/s13256-023-04161-z
 received in 2022-01-26, accepted in 2023-09-01,  发布年份 2023
来源: Springer
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【 摘 要 】

BackgroundHuntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions). When the personality changes become noticeable, involuntary movements (chorea) also develop. The disease is caused by the CAG repeat expansion in the coding region of the HTT gene, and the diagnosis is based on the presence of this expansion. However, there is currently no effective treatment for the progression of Huntington’s disease and its involuntary motor symptoms. Herein, we present a case in which memantine was effective in treating the chorea movements of Huntington’s disease.Case presentationA 75-year-old Japanese woman presented to the hospital with involuntary movements of Huntington’s disease that began when she was 73 years old. In a cerebral blood flow test (N-isopropyl-p-iodoamphetamine–single-photon emission computed tomography), decreased blood flow was observed in the precuneus (anterior wedge) and posterior cingulate gyrus. Usually, such areas of decreased blood flow are observed in patients with Alzheimer’s-type dementia. So, we administered memantine for Alzheimer’s-type dementia, and this treatment suppressed the involuntary movements of Huntington’s disease, and the symptoms progressed slowly for 7 years after the onset of senility. In contrast, her brother died of complications of pneumonia during the course of Huntington’s disease.ConclusionsWe recorded changes in parameters such as the results of the N-isopropyl-p-iodoamphetamine–single-photon emission computed tomography and gait videos over 7 years. Treatment with memantine prevented the chorea movement and the progression of Huntington’s disease. We believe this record will provide clinicians with valuable information in diagnosing and treating Huntington’s disease.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
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