Impact of early fructose intake on metabolic profile and aerobic capacity of rats

Lipids in Health and Disease

Research

Ana C Ghezzi¹  José D Botezelli¹  Maria AR Mello¹  Carla Ribeiro¹  Lucieli T Cambri¹ 

[1] São Paulo State University - UNESP Department of Physical Education, Av: 24-A, 1515 Bela Vista, Zip code: 13506-900, São Paulo, Rio Claro, Brazil;

关键词: Insulin Resistance;    Metabolic Syndrome;    Fructose;    Aerobic Capacity;    Blood Lactate Concentration;   

DOI  :  10.1186/1476-511X-10-3

 received in 2010-11-26, accepted in 2011-01-11,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundMetabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in prevention and treatment of metabolic syndrome, this study examined the metabolic profile and the aerobic capacity of rats kept early in life on a fructose-rich diet, a substrate that has been associated with metabolic syndrome.MethodsWe used adult female Wistar rats fed during pregnancy and lactation with two diets: balanced or fructose-rich 60%. During breastfeeding, the pups were distributed in small (4/mother) or adequate (8/mother) litters. At 90 days of age, they were analyzed with respect to: glucose tolerance, peripheral insulin sensitivity, aerobic capacity and serum glucose, insulin, triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol concentrations as well as measures of glycogen synthesis and glucose oxidation by the soleus muscle.ResultsIt was found that the fructose rich diet led the animals to insulin resistance. The fructose fed rats kept in small litters also showed dyslipidemia, with increased serum concentrations of total cholesterol and triglycerides.ConclusionNeither the aerobic capacity nor the glucose oxidation rates by the skeletal muscle were altered by fructose-rich diet, indicating that the animal model evaluated is potentially interesting for the study of the role of exercise in metabolic syndrome.

【 授权许可】

CC BY   
© Ghezzi et al; licensee BioMed Central Ltd. 2011