Structured triacylglycerol containing behenic and oleic acids suppresses triacylglycerol absorption and prevents obesity in rats

Lipids in Health and Disease

Research

Kiyoharu Takamatsu¹  Nobuhiko Tachibana¹  Mitsutaka Kohno¹  Motohiko Hirotsuka²  Makiko Kojima²  Satoshi Seino³  Ikuo Ikeda³  Ayako Izumisawa³  Takashi Yamahira³  Nobuo Sagi⁴  Toshiharu Arishima⁴ 

[1] Food Science Research Institute, Fuji Oil Co., Ltd., 1 Sumiyoshi-cho, Izumisano-shi, 598-8540, Osaka, Japan;Food Science Research Institute, Fuji Oil Co., Ltd., 4-3 Kinunodai, 300-2497, Tsukubamirai-shi, Ibaraki, Japan;Laboratory of Food and Biomolecular Science, Department of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, 981-8555, Sendai, Miyagi, Japan;Oils & Fats Development Department, Fuji Oil Co., Ltd., 1 Sumiyoshi-cho, Izumisano-shi, 598-8540, Osaka, Japan;

关键词: Pancreatic Lipase;    Total Cholesterol Concentration;    Behenic Acid;    Test Emulsion;    Trioleoylglycerol;   

DOI  :  10.1186/1476-511X-9-77

 received in 2010-06-04, accepted in 2010-07-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundDietary 1(3)-behenoyl-2,3(1)-dioleoyl-rac-glycerol (BOO) has been reported to inhibit pancreatic lipase activity in vitro and suppress postprandial hypertriacylglycerolemia in humans. In the present study, the anti-obesity activities of BOO and its inhibitory effects on lymphatic triacylglycerol (TAG) absorption were investigated in rats.MethodsIn Experiment 1, rats were fed either BOO or soybean oil (SO) diet for 6 weeks. In the BOO diet, 20% of SO was replaced with an experimental oil rich in BOO. In Experiments 2 and 3, rats cannulated in the thoracic duct were administered an emulsions containing trioleoylglycerol (OOO) or an oil mixture (OOO:BOO, 9:1). Tri[1-14C]oleoylglycerol (14C-OOO) was added to the emulsions administered in Experiment 3.ResultsNo observable differences were detected in food intake or body weight gain between the BOO and SO groups in Experiment 1. Plasma and liver TAG concentrations and visceral fat weights were significantly lower in the BOO group than in the SO group. The apparent absorption rate of fat was significantly lower in the BOO group than in the SO group. In Experiment 2, the lymphatic recovery of oleic and behenic acids was significantly lower at 5 and 6 h after BOO administration than after OOO administration. In Experiment 3, the lymphatic recovery of 14C-OOO was significantly lower at 5 and 6 h after BOO administration than after OOO administration.ConclusionsThese results suggest that BOO prevents deposition of visceral fat and hepatic TAG by lowering and delaying intestinal absorption of TAG.

【 授权许可】

CC BY   
© Kojima et al; licensee BioMed Central Ltd. 2010