Characteristics of High-density Lipoprotein Subclasses Distribution for Subjects with Desirable Total Cholesterol Levels

Lipids in Health and Disease

Research

Yanhua Xu¹  Yinghui Liu²  Shiyin Long²  Mingde Fu³  Lianqun Jia³  Li Tian³ 

[1] Chengdu Hoist Biotechnology Co., LTD, Sichuan, PR China;Department of Biochemistry and Molecular Biology, University of South China, Hengyang, Hunan, People's Republic of China;Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China;

关键词: Total Cholesterol;    Total Cholesterol Level;    High Density Lipoprotein;    Total Cholesterol Concentration;    High Total Cholesterol;   

DOI  :  10.1186/1476-511X-10-64

 received in 2011-03-28, accepted in 2011-04-22,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTo investigate alteration of high density lipoproteins (HDL) subclasses distribution in different total cholesterol (TC) levels, mainly the characteristics of HDL subclasses distribution in desirable TC levels and analyze the related mechanisms.MethodsApoA-I contents of plasma HDL subclasses were determined by 2-dimensional gel electrophoresis coupled with immunodetection. 486 Chinese Adults subjects were assigned to different TC groups according to the third Report of NCEP (ATP- III) guidelines.ResultsThe increase in contents of small preβ1-HDL, HDL3c, HDL3b, and HDL3a particles clustered and reduce in HDL2b with increased of TC. The distribution of HDL subclasses have shown abnormality characterized by the lower HDL2b (324.2 mg/L) contents and the higher preβ1-HDL (90.4 mg/L) contents for desirable TC Chinese subjects. Among 176 desirable TC subjects, 58.6% subjects with triglyceride (TG) < 2.26 mmol/L, 61.2% subjects with HDL-C ≥1.03 mmol/L and 88.6% subjects with low density lipoprotein cholesterol(LDL-C) < 3.34 mmol/L, and the profile of HDL subclasses distribution for above these subjects was reasonable.ConclusionsThe particles size of HDL subclasses shifted towards smaller with increased TC levels. The TC was liner with HDL2b contents and those can be reduced 17 mg/L for 0.5 mmol/L increment in TC levels. The HDL subclasses distribution phenotype was not expectation for Chinese Population with desirable TC levels. Thus, from the HDL subclasses distribution point, when assessing the coronary heart disease(CHD) risk not only rely on the TC levels, but also the concentrations of TG, HDL-C and LDL-C must considered in case the potential risk for desirable TC subjects with other plasma lipids metabolism disorders.

【 授权许可】

Unknown   
© Tian et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.