Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study

Lipids in Health and Disease

Research

Ravindra M Pandey¹  Seema Gulati²  Anoop Misra³ 

[1] All India Institute of Medical Sciences (AIIMS), New Delhi, India;Diabetes Foundation (India), Safdarjung Development Area, New Delhi, India;National Diabetes, Obesity, and Cholesterol Foundation (N-DOC), Safdarjung Development Area, New Delhi, India;Center of Nutrition & Metabolic Research (C-NET), SDA, New Delhi, India;Diabetes Foundation (India), Safdarjung Development Area, New Delhi, India;National Diabetes, Obesity, and Cholesterol Foundation (N-DOC), Safdarjung Development Area, New Delhi, India;Center of Nutrition & Metabolic Research (C-NET), SDA, New Delhi, India;Fortis C-DOC Center for Excellence for Diabetes, Metabolic Diseases and Endocrinology, B-16, Chirag Enclave, -110048, New Delhi, India;Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India;

关键词: Total Cholesterol;    Bile Acid;    Glucan;    Serum Triglyceride;    Total Cholesterol Level;   

DOI  :  10.1186/s12944-017-0460-3

 received in 2016-10-15, accepted in 2017-03-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCardiovascular diseases are more prevalent and severe in Asian Indians. Simple diet-based strategies are important for prevention of cardiovascular diseases.The aim of the present study was to evaluate the effects of oats consumption on lipid parameters in mildly hypercholesterolemic Asian Indians living in India.MethodsA short-term, prospective, open-labeled, randomized controlled, parallel group study was conducted. Mildly hypercholesterolemic (total cholesterol >200 mg/dL and <240 mg/dL) subjects (n = 80) were randomized into two groups: intervention (n = 40) and usual diet (n = 40). Sample size was calculated for a two-group parallel superiority randomized control trial. Out of 80 enrolled subjects 69 subjects completed the study; 33 in the control group and 36 in the intervention group. In the intervention group, patients were served 70 g of oats twice a day in the form of porridge and upma (A thick porridge from oats with seasonings and vegetables) under observation at the study site. Lipid parameters were assessed at baseline and after 4 weeks of intervention.ResultsThere was a reduction of 3.1% in total cholesterol levels in the control group as against 8.1% reduction in the intervention group (p < 0.02). Greater reductions were also seen in low-density lipoprotein cholesterol in the intervention group (11.6%) as compared to control group (4.1%, p < 0.04) over a period of 28 days.ConclusionDaily consumption of 3 g of soluble fiber from 70 g of oats leads to beneficial effects on the lipid parameters, specifically total cholesterol and low-density lipoprotein cholesterol in hypercholesterolemic Asian Indians. Large scale studies over a longer period of intervention are required to further establish the cholesterol-lowering effect of oat fiber.Trial registrationThe study was retrospectively registered at clinicaltrials.gov (dated: 25th Februrary.2015) with registration number NCT02376660.

【 授权许可】

CC BY   
© The Author(s). 2017