GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?

Cardiovascular Diabetology

Original Investigation

István Wittmann¹  Judit Cseh¹  Márton Mohás¹  Katalin Hetyésy²  Veronika Csöngei³  Anita Maász³  Noémi Polgár³  Béla Melegh³  Luca Járomi³  Péter Kisfali³  Enikő Sáfrány³  Katalin Sümegi³  Eszter Fehér⁴ 

[1] 2nd Department of Medicine and Nephrological Center, University of Pécs, Pacsirta 1, H-7624, Pécs, Hungary;Central Laboratory, Aladár Petz Hospital, Vasvári Pál 2, H-9024, Győr, Hungary;Department of Medical Genetics, University of Pécs, Szigeti 12, H-7624, Pécs, Hungary;Department of Radiology, University of Pécs, Ifjúság 13, H-7624, Pécs, Hungary;

关键词: Plasma Glucose Level;    Serum Triglyceride;    Fast Plasma Glucose Concentration;    Metabolic Syndrome Patient;    Lower Plasma Glucose;   

DOI  :  10.1186/1475-2840-9-79

 received in 2010-09-13, accepted in 2010-11-29,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundRecent studies revealed that glucokinase regulatory protein (GCKR) variants (rs780094 and rs1260326) are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the association of these two variants with the lipid profile and plasma glucose levels in Hungarian subjects with type 2 diabetes mellitus and metabolic syndrome; and also correlated the genotypes with the carotid intima-media thickness records.MethodsA total of 321 type 2 diabetic patients, 455 metabolic syndrome patients, and 172 healthy controls were genotyped by PCR-RFLP.ResultsBoth GCKR variants were found to associate with serum triglycerides and with fasting plasma glucose. However, significant association with the development of type 2 diabetes mellitus and metabolic syndrome could not be observed. Analyzing the records of the patients, a positive association of prevalence the GCKR homozygous functional variants and carotid intima-media thickness was found in the metabolic syndrome patients.ConclusionsOur results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. Besides this positive replication, as a novel feature, our preliminary findings also suggest a cardiovascular risk role of the GCKR minor allele carriage based on the carotid intima-media thickness association.

【 授权许可】

CC BY   
© Mohás et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.