Composition of fatty acids in plasma and erythrocytes and eicosanoids level in patients with metabolic syndrome

Lipids in Health and Disease

Review

Natalia V Zhukova¹  Marina V Antonyuk²  Tatyana A Kantur²  Tatyana P Novgorodtseva²  Elena G Lobanova²  Yulia K Karaman² 

[1] Institute of marine biology of name A.V. Zhirmunskogo of the Far East department the Russian academy of sciences, Vladivostok, Russia;Vladivostok Branch of the Far Eastern Center of Physiology and Pathology of Respiration of SB RAMN, Institute of Medical Climatology and Rehabilitative Treatment, Russia;

关键词: Eicosanoid;    Metabolic Syndrome Component;    Eicosanoid Synthesis;    Metabolic Syndrome Patient;    Group Metabolic Syndrome;   

DOI  :  10.1186/1476-511X-10-82

 received in 2011-03-23, accepted in 2011-05-19,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundDisturbances of the fatty acids composition in plasma and red blood cells and eicosanoid synthesis play an important role in the metabolic syndrome (MS) formation.MethodsThe observation group included 61 people with metabolic syndrome (30 patients with MS and normal levels of insulin, 31 people with MS and insulin resistance - IR). The parameters of carbohydrate and lipid metabolism in blood serum were examined. The composition of nonesterified fatty acids (NEFA), fatty acid (FA) of red blood cells lipids was analyzed by gas-liquid chromatography. Eicosanoids level in MS patients blood serum was studied by enzyme immunoassay.ResultsIn MS patients in the absence of glucose-insulin homeostasis disturbances and in patients with IR the accumulation of polyunsaturated fatty acids (18:2 n6, 18:3 n3, 22:4 n6) and lower pool of saturated FA (12:0, 14:0, 16: 0, 17:0) in plasma were discovered. A deficit of polyunsaturated FA (18:3 n3, 20:4 n6) with a predominance of on-saturated FA (14:0, 18:0) in erythrocyte membranes was revealed. In MS patients regardless of the carbohydrate metabolism status high levels of leukotriene B4 and 6-keto-prostaglandin-F1α in serum were found. The development of IR in MS patients leads to increased synthesis of thromboxane A2.ConclusionThe results revealed a disturbance in nonesterified fatty acids of plasma lipids and red blood cells, eicosanoid synthesis in MS patients. The breach of the plasma and cell membranes fatty acids compositions, synthesis of vasoactive and proinflammatory eicosanoids is an important pathogenetic part of the MS development.

【 授权许可】

Unknown   
© Novgorodtseva et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.