Effects of heart failure and coronary artery disease on erectile dysfunction: a two-sample mendelian randomization study

BMC Urology

Research

Kaiyang Shao¹  Ruying Hu¹  Yaling Li¹  Jianqiao Zhang¹  Huiyan Zheng¹  Ting Sun¹  Weikang Chen² 

[1] The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road,Shangcheng District Hangzhou, 310009, Hangzhou, Zhejiang, China;Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;

关键词: Mendelian randomization;    Heart failure;    Coronary artery disease;    Erectile dysfunction;    Causal association;   

DOI  :  10.1186/s12894-023-01335-1

 received in 2023-03-08, accepted in 2023-10-05,  发布年份 2023

来源: Springer

【 摘 要 】

Background and aimsThere are no clear conclusions as to whether heart failure (HF) and coronary heart disease (CAD) increase the risk of erectile dysfunction (ED).In our study, we used Mendelian randomization (MR) analysis to discover a causal relationship between HF, CAD and ED.MethodsSingle nucleotide polymorphisms (SNPs) associated with HF, CAD and ED were obtained from the MRC IEU Open Genome-Wide Association Study (GWAS) database.After a series of screenings, the remaining SNPs were selected as instrumental variables (IVs) for HF and CAD for MR analysis to assess the relationship between genetically predicted HF or CAD and the pathogenesis of ED.Among them, we used the random-effects inverse variance weighted (IVW) method as the primary analysis method.Finally, Cochran’s q-test, funnel plots, MR-Egger regression, Leave-one-out method and MR-PRESSO were used for sensitivity analysis.ResultsIn the IVW method, there was no significant causal relationship between genetically predicted HF and CAD and the incidence of ED.(HF: OR = 1.17, 95% CI 0.99–1.39; p = 0.074;CAD: OR = 1.08, 95% CI 0.99–1.17, p = 0.068)。The results of sensitivity analyses supported our conclusion that no horizontal pleiotropism was found.ConclusionThis study did not find a causal relationship between HF or CAD and ED in European populations, which requires further in-depth research.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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