Regulatory T cells in skin regeneration and wound healing

Military Medical Research

Review

Ulrich Kneser¹  Gabriel Hundeshagen¹  Leila Harhaus¹  Dennis P. Orgill²  Adriana C. Panayi³  Samuel Knoedler⁴  Leonard Knoedler⁵  Martin Kauke-Navarro⁵  Bohdan Pomahac⁵  Yuval Rinkevich⁶ 

[1] Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071, Ludwigshafen, Germany;Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, MA, USA;Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, MA, USA;Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071, Ludwigshafen, Germany;Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, MA, USA;Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, 06510, New Haven, CT, USA;Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, 85764, Munich, Germany;Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, 06510, New Haven, CT, USA;Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, 85764, Munich, Germany;

关键词: Regulatory T cells (Tregs);    Wound healing;    Wound repair;    Skin injury;    Skin regeneration;   

DOI  :  10.1186/s40779-023-00484-6

 received in 2023-03-26, accepted in 2023-10-04,  发布年份 2023

来源: Springer

【 摘 要 】

As the body’s integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality. To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. Such temporally- and spatially-coordinated interplay necessitates tight regulation to prevent collateral damage such as overshooting immune responses and excessive inflammation. In this context, regulatory T cells (Tregs) hold a key role in balancing immune homeostasis and mediating cutaneous wound healing. A comprehensive understanding of Tregs’ multifaceted field of activity may help decipher wound pathologies and, ultimately, establish new treatment modalities. Herein, we review the role of Tregs in orchestrating the regeneration of skin adnexa and catalyzing healthy wound repair. Further, we discuss how Tregs operate during fibrosis, keloidosis, and scarring.

【 授权许可】

CC BY   
© People´s Military Medical Press 2023

【 图 表 】

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