Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study

BMC Medicine

Research Article

Farin Kamangar¹  Reza Malekzadeh²  Arash Etemadi³  Farhad Islami⁴  Christian C Abnet⁵  Sanford M Dawsey⁵  Ashkan Emadi⁶  Paolo Boffetta⁷  Paul Brennan⁸  Hossein Poustchi⁹  Akram Pourshams⁹ 

[1] Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, USA;Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran;Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran;Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr, 20859, Bethesda, MD, USA;Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran;Surveillance and Health Services Research, American Cancer Society, Atlanta, GA, USA;Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr, 20859, Bethesda, MD, USA;Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA;Institute for Translational Epidemiology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA;International Agency for Research on Cancer, Lyon, France;Liver and Pancreatobiliary Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Blood group;    ABO;    Rh;    Mortality;    Cancer;    Cardiovascular disease;   

DOI  :  10.1186/s12916-014-0237-8

 received in 2014-09-04, accepted in 2014-11-12,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundA few studies have shown an association between blood group alleles and vascular disease, including atherosclerosis, which is thought to be due to the higher level of von Willebrand factor in these individuals and the association of blood group locus variants with plasma lipid levels. No large population-based study has explored this association with overall and cause-specific mortality.MethodsWe aimed to study the association between ABO blood groups and overall and cause-specific mortality in the Golestan Cohort Study. In this cohort, 50,045 people 40- to 70-years old were recruited between 2004 and 2008, and followed annually to capture all incident cancers and deaths due to any cause. We used Cox regression models adjusted for age, sex, smoking, socioeconomic status, ethnicity, place of residence, education and opium use.ResultsDuring a total of 346,708 person-years of follow-up (mean duration 6.9 years), 3,623 cohort participants died. Non-O blood groups were associated with significantly increased total mortality (hazard ratio (HR) = 1.09; 95% confidence interval (CI): 1.01 to 1.17) and cardiovascular disease mortality (HR = 1.15; 95% CI: 1.03 to 1.27). Blood group was not significantly associated with overall cancer mortality, but people with group A, group B, and all non-O blood groups combined had increased risk of incident gastric cancer. In a subgroup of cohort participants, we also showed higher plasma total cholesterol and low-density lipoprotein (LDL) in those with blood group A.ConclusionsNon-O blood groups have an increased mortality, particularly due to cardiovascular diseases, which may be due to the effect of blood group alleles on blood biochemistry or their effect on von Willebrand factor and factor VIII levels.Please see related commentary 10.1186/s12916-014-0250-y.

【 授权许可】

CC BY   
© Etemadi et al.; licensee BioMed Central. 2015