In vitro potency of amikacin and comparators against E. coli,K. pneumoniae and P. aeruginosa respiratory and blood isolates

Annals of Clinical Microbiology and Antimicrobials

Research

Christina A. Sutherland¹  Jamie E. Verastegui¹  David P. Nicolau² 

[1] Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, 06102, Hartford, CT, USA;Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, 06102, Hartford, CT, USA;Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA;

关键词: Amikacin;    E. coli;    K. pneumoniae;    P. aeruginosa;   

DOI  :  10.1186/s12941-016-0155-z

 received in 2016-04-18, accepted in 2016-06-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to define the potency of amikacin and comparator agents against a collection of blood and respiratory nosocomial isolates implicated in ICU based pulmonary infections gathered from US hospitals.MethodsMinimum inhibitory concentrations of amikacin, aztreonam, cefepime, ceftazidime, ceftolozane/tazobactam, ceftriaxone, ciprofloxacin, imipenem, meropenem, piperacillin/tazobactam and tobramycin were tested against 2460 Gram-negative isolates. Amikacin had 96 % susceptibility against the combined E. coli and K. pneumoniae isolates and 95 % susceptibility against P. aeruginosa.ResultsNinety-six percent of all of isolates tested were susceptible (i.e., MICs ≤16 mg/L) to amikacin by current laboratory standards which demonstrates a high level of activity to combat infections caused by these organisms including ESBL, MDR, β-lactam and fluoroquinolone resistant strains. Moreover, 99 % of all organisms had amikacin MICs ≤64 mg/L.ConclusionsOverall, these data highlight the continued potency of amikacin and suggest that the achievable lung concentrations of approximately 5000 mg/L with the administration of the amikacin by inhalation (Amikacin Inhale, BAY41-6551) will exceed the MICs typically observed for P. aeruginosa, E. coli and K. pneumoniae in the hospital setting.

【 授权许可】

CC BY   
© The Author(s) 2016