Multi-drug resistant Pseudomonas aeruginosa and Klebsiella pneumoniae circulation in a burn hospital, Tehran, Iran

GMS Hygiene and Infection Control

卷:14

Alinejad, Faranak¹  Lari, Abdolaziz Rastegar²  Alaghehbandan, Reza³  Asadian, Mahla⁴  Azimi, Leila⁵ 

[1] Burn Research Center, Iran University of Medical Sciences, Tehran, Iran;

[2] Department of Microbiology, Iran University of Medical Sciences, Tehran, Iran;

[3] Department of Pathology, University of British Columbia, Royal Columbian Hospital, Vancouver, BC, Canada;

[4] Division of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;

[5] Pediatric Infectious Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: health care-associated infection;    P. aeruginosa;    K. pneumoniae;    antibiotic resistance;    genetic relationship;    pulsed-field gel electrophoresis;   

DOI  :  10.3205/dgkh000317

来源: DOAJ

【 摘 要 】

andare among the most important Gram-negative bacteria that can cause nosocomial infections, especially in burn patients. It is important to determine genetic relationships in different clinical specimens as well as between clinical and environmental specimens, which can aid in detecting the source of infection. The aim of this study was to investigate multi-drug resistantandspread in a burn hospital, Tehran, Iran. After identification, antibiotic susceptibility testing of all isolates was conducted according to the CLSI guidelines. Further, pulsed-field gel electrophoresis (PFGE) was performed for molecular typing. 97 clinical and 33 environmental specimens were collected. 40 (55%) clinical strains ofandwere highly drug resistant. PFGE findings showed similar genetic features to those seen in multi-drug resistantand/or extensively drug resistantandin clinical and environmental isolates. Inhibition of bacterial spread in the hospital can help to control health care-associated infection and subsequently decrease the morbidity and mortality in hospitalized patients, particularly immunocompromised populations such as burn patients.

【 授权许可】

Unknown