Magnetic separation-based blood purification: a promising new approach for the removal of disease-causing compounds?

Journal of Nanobiotechnology

Review

A A Schlegel¹  R Graf¹  W J Stark²  Beatrice Beck-Schimmer³  I K Herrmann³ 

[1] Department of Surgery, Swiss HPB and Transplant Center, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland;Institute for Chemical and Bioengineering, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland;Institute of Anesthesiology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland;Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland;

关键词: Blood purification;    Intoxication;    Magnetic separation;    Magnetic nanoparticles;    Sepsis;   

DOI  :  10.1186/s12951-015-0110-8

 received in 2015-06-09, accepted in 2015-07-29,  发布年份 2015

来源: Springer

【 摘 要 】

Recent studies report promising results regarding extracorporeal magnetic separation-based blood purification for the rapid and selective removal of disease-causing compounds from whole blood. High molecular weight compounds, bacteria and cells can be eliminated from blood within minutes, hence offering novel treatment strategies for the management of intoxications and blood stream infections. However, risks associated with incomplete particle separation and the biological consequences of particles entering circulation remain largely unclear. This article discusses the promising future of magnetic separation-based purification while keeping important safety considerations in mind.

【 授权许可】

CC BY   
© Herrmann et al. 2015