Magnetic separation-based blood purification: a promising new approach for the removal of disease-causing compounds?

Journal of Nanobiotechnology

Beatrice Beck-Schimmer¹  W J Stark²  R Graf³  A A Schlegel³  I K Herrmann¹ 

[1] Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, Zurich, 8057, Switzerland;Institute for Chemical and Bioengineering, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zurich, 8093, Switzerland;Department of Surgery, Swiss HPB and Transplant Center, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland

关键词: Sepsis;    Magnetic nanoparticles;    Magnetic separation;    Intoxication;    Blood purification;   

Others  :  1224850
DOI  :  10.1186/s12951-015-0110-8

 received in 2015-06-09, accepted in 2015-07-29,  发布年份 2015

【 摘 要 】

Recent studies report promising results regarding extracorporeal magnetic separation-based blood purification for the rapid and selective removal of disease-causing compounds from whole blood. High molecular weight compounds, bacteria and cells can be eliminated from blood within minutes, hence offering novel treatment strategies for the management of intoxications and blood stream infections. However, risks associated with incomplete particle separation and the biological consequences of particles entering circulation remain largely unclear. This article discusses the promising future of magnetic separation-based purification while keeping important safety considerations in mind.

【 授权许可】

   
2015 Herrmann et al.

【 图 表 】

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