A HELLP syndrome complicates a gestational trophoblastic neoplasia in a perimenopausal woman: a case report

BMC Cancer

Case Report

François Golfier¹  Béatrice Weber²  Agnès Leroux³  Guillaume Vogin⁴  Touria Hajri⁵ 

[1] Department of Obstetrics and Gynaecology, Lyon Sud University Hospital, Lyon, France;French Trophoblastic Disease Reference Centre, Lyon Sud University Hospital, Lyon, France;Department of Oncology, Institut de Cancérologie de Lorraine, Vandoeuvre les Nancy, France;Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Avenue de Bourgogne, 54500, Vandoeuvre Les Nancy, France;Department of Pathology, Institut de Cancérologie de Lorraine, Vandoeuvre les Nancy, France;Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Avenue de Bourgogne, 54500, Vandoeuvre Les Nancy, France;French Trophoblastic Disease Reference Centre, Lyon Sud University Hospital, Lyon, France;

关键词: Preeclampsia;    HELLP syndrome;    Gestational trophoblastic neoplasia;    Perimenopause;   

DOI  :  10.1186/s12885-016-2641-2

 received in 2016-01-21, accepted in 2016-07-28,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01–0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated with partial moles, another rare complication of pregnancy. This manuscript describes the only reported case of HELLP syndrome associated with a complete invasive hydatiform mole.Case presentationWe report a perimenopausal patient in prolonged remission from an uncommon high-risk invasive complete mole. The diagnosis was set in a context of early onset preeclampsia and HELLP syndrome. The development of life-threatening complications required primary hysterectomy. Postoperative hCG quickly returned to normal with EMA/CO multi-agent chemotherapy.ConclusionOur patient is in prolonged remission from a complete mole complicated with EOP and HELLP syndrome. This exceptional case of complicated gestational trophoblastic neoplasia reflects a very rare condition in which several risk factors for placental ischemia are associated. Emergency hysterectomy should be considered as salvage initial treatment in such life-threatening situations.

【 授权许可】

CC BY   
© The Author(s). 2016