Significantly greater triglyceridemia in Black African compared to White European men following high added fructose and glucose feeding: a randomized crossover trial

Lipids in Health and Disease

Short Report

Martin B. Whyte¹  Miriam Samuel²  Scott V. Harding²  Louise M. Goff³ 

[1] Department of Diabetes and Metabolic Medicine, University of Surrey, Wolfson Unit for Translational Research, Postgraduate Medical School, Daphne Jackson Road, GU2 7WG, Guildford, UK;Division of Diabetes and Nutritional Sciences, King’s College London, Franklin-Wilkins Building, Stamford Street, SE1 9NH, London, UK;Division of Diabetes and Nutritional Sciences, King’s College London, Franklin-Wilkins Building, Stamford Street, SE1 9NH, London, UK;Division of Diabetes and Nutritional Sciences, King’s College London, Henriette Raphael Building, Room 2.29, Guy’s Campus, SE1 1UL, London, UK;

关键词: Ethnicity;    Fructose;    Insulin;    Triglycerides;    Postprandial;   

DOI  :  10.1186/s12944-016-0315-3

 received in 2016-05-28, accepted in 2016-08-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundBlack African (BA) populations are losing the cardio-protective lipid profile they historically exhibited, which may be linked with increasing fructose intakes. The metabolic effects of high fructose diets and how they relate to blood lipids are documented for Caucasians, but have not been described in BA individuals.ObjectiveThe principle objective of this pilot study was to assess the independent impacts of high glucose and fructose feeding in men of BA ancestry compared to men of White European (WE) ancestry on circulating triglyceride (TG) concentrations.MethodsHealthy males, aged 25–60 years, of BA (n = 9) and WE (n = 11) ethnicity were randomly assigned to 2 feeding days in a crossover design, providing mixed nutrient meals with 20 % total daily caloric requirements from either added glucose or fructose. Circulating TG, non-esterified fatty acids (NEFA), glucose, insulin and C-peptide were measured over two 24-h periods.ResultsFasting TGs were lower in BAs than WEs on the fructose feeding day (p < 0.05). There was a trend for fasting TG concentrations 24 h following fructose feeding to increase in both BA (baseline median fasting: 0.80, IQR 0.6–1.1 vs 24-h median post-fructose: 1.09, 0.8–1.4 mmol/L; p = 0.06) and WE (baseline median fasting 1.10, IQR 0.9–1.5 vs 24-h median post-fructose: 1.16, IQR 0.96–1.73 mmol/L; p = 0.06). Analysis within ethnic group demonstrated that in TG iAUC was significantly higher in BA compared to WE on both glucose (35, IQR 11–56 vs −4, IQR −10–1 mmol/L/min; p = 0.004) and fructose (48, IQR 15–68 vs 13, IQR −7–38 mmol/L/min; p = 0.04). Greater suppression of postprandial NEFA was evident in WE than BA after glucose feeding (−73, IQR −81– −52 vs −26, IQR −48– −3 nmol/L/min; p = 0.001) but there was no ethnic difference following fructose feeding.ConclusionsUnderstanding the metabolic effects of dietary acculturation and Westernisation that occurs in Black communities is important for developing prevention strategies for chronic disease development. These data show postprandial hypertriglyceridemia following acute feeding of high added fructose and glucose in BA men, compared to WE men, may contribute to metabolic changes observed during dietary acculturation and Westernisation.Trial registrationThe study was retrospectively registered on clinicaltrials.gov: NCT02533817.

【 授权许可】

CC BY   
© The Author(s). 2016