Maternal dietary free or bound fructose diversely influence developmental programming of lipogenesis

Lipids in Health and Disease

Research

Reyhan Nergiz-Unal¹  Armagan Aytug Yuruk¹ 

[1] Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, 06100, Ankara, Turkey;

关键词: Fetal programming;    Fructose;    Insulin;    Non-esterified fatty acids;    Triglyceride;   

DOI  :  10.1186/s12944-017-0618-z

 received in 2017-03-06, accepted in 2017-11-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMaternal dietary choices throughout preconception, pregnancy, and lactation irreversibly affect the development of fetal tissues and organs, known as fetal programming. Recommendations tend to emphasize reducing added sugars. However, the impact of maternal dietary free or bound fructose in added sugars on developmental programming of lipogenesis is unknown.MethodsVirgin Sprague-Dawley rats were randomly divided into five groups. Rats were given feed and plain water (control) or water containing maltodextrin (vehicle), fructose, high-fructose corn syrup (HFCS) containing 55% fructose, sucrose (20% w/v) for 12 weeks before mating and throughout the pregnancy and lactation periods. Body weight, water, and feed intake were measured throughout the study. At the end of the lactation period, blood was drawn to determine the fasting levels of glucose, insulin, triglycerides, and non-esterified fatty acids (NEFA) in blood. Triglycerides and acetyl Co-A Carboxylase-1 (ACC1) levels in livers were analyzed, and insulin resistance was calculated.ResultsThe energy intake of dams in the HFCS group was higher than in the fructose group, while weight gain was less in the HFCS group than in the fructose group. HFCS resulted in greater insulin resistance in dams, whereas free fructose had a robust effect on the fetal programming of insulin resistance. Free fructose and HFCS in the maternal diet increased blood and liver triglycerides and NEFA content in pups. Furthermore, fructose and HFCS exposure increased phosphorylated ACC1 as compared to maltodextrin and control, indicating greater fatty acid synthesis in pups and dams.ConclusionDifferent types of added sugar in the maternal diet have different metabolic effects on the developmental programming of lipogenesis. Consequently, high fructose intake via processed foods may increase the risk for chronic diseases, and free fructose might contribute to developmental programming of chronic diseases more than bound fructose.

【 授权许可】

CC BY   
© The Author(s). 2017