Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model

Cardiovascular Diabetology

Original Investigation

Rogério Brandão Wichi¹  Nathalia Edviges Alves Lima²  Bruno Rodrigues²  Eduardo Morvan²  Laura Beatriz Mesiano Maifrino³  Jacqueline Freire Machi⁴  Maria Cláudia Irigoyen⁴  Cristiano Mostarda⁴  Kátia De Angelis⁵ 

[1] Federal University of Sergipe, Aracajú/SE, Brazil;Human Movement Laboratory, Sao Judas Tadeu University, Av. Taquari, 546, 03166-000, São Paulo/SP, Brazil;Human Movement Laboratory, Sao Judas Tadeu University, Av. Taquari, 546, 03166-000, São Paulo/SP, Brazil;Institute of Cardiology Dante Pazzaneze, São Paulo/SP, Brazil;Hypertension Unit, Heart Institute (InCor), Medical School of University of Sao Paulo, São Paulo/SP, Brazil;Translational Physiology Laboratory, Nove de Julho University, São Paulo/SP, Brazil;

关键词: Fructose;    Exercise training;    Triglycerides;    Insulin resistance;    Baroreflex sensitivity;    Cardiovascular remodeling;    Aorta remodeling;   

DOI  :  10.1186/1475-2840-12-89

 received in 2013-03-13, accepted in 2013-06-05,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise training (LET) on metabolic, hemodynamic, ventricular and vascular morphological changes induced by fructose drinking in male rats.MethodsMale Wistar rats were divided into (n = 8 each) control (C), sedentary fructose (F) and ET fructose (FT) groups. Fructose-drinking rats received D-fructose (100 g/l). FT rats were assigned to a treadmill training protocol at low intensity (30% of maximal running speed) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, white adipose tissue (WAT) and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BS) was evaluated by the tachycardic and bradycardic responses. Right atria, left ventricle (LV) and ascending aorta were prepared to morphoquantitative analysis.ResultsLET reduced WAT (−37.7%), triglyceride levels (−33%), systolic AP (−6%), heart weight/body weight (−20.5%), LV (−36%) and aortic (−76%) collagen fibers, aortic intima-media thickness and circumferential wall tension in FT when compared to F rats. Additionally, FT group presented improve of BS, numerical density of atrial natriuretic peptide granules (+42%) and LV capillaries (+25%), as well as the number of elastic lamellae in aorta compared with F group.ConclusionsOur data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS.

【 授权许可】

Unknown   
© Morvan et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.