Radiological findings of malignant peripheral nerve sheath tumor: reports of six cases and review of literature

World Journal of Surgical Oncology

Research

Jing Ye¹  Jing-tao Wu¹  Yong-hui Yu¹  Ming-xiang Chen¹ 

[1] Department of Medical Imaging, Subei People’s Hospital of Jiangsu Province, 98# Western Nantong Road, 225001, Yangzhou, China;

关键词: Nervous-peripheral;    Tomography;    X-ray computer;    MR imaging;   

DOI  :  10.1186/s12957-016-0899-0

 received in 2016-02-04, accepted in 2016-05-03,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMalignant peripheral nerve sheath tumor (MPNST) is a kind of rare neurogenic tumor. If associated with neurofibromatosis type 1, MPNST usually has a higher mortality. The aim of the article is to assess the imaging characteristics of MPNST and compare them with those of benign peripheral nerve sheath tumor (BPNST) to characterize this tumor.MethodsClinical and imaging data of six cases with MPNST and 28 cases with BPNST in our institution since 2011 were retrospectively reviewed. Thirty-three patients have available MR imaging data, and two patients of MPNST also accepted CT scan. One patient accepted CT scan only. Location, size, shape, signal or density, boundary, bone destruction, relation to adjacent nerve, contrast-enhanced features as well as some other signs were assessed and compared with statistical software. Student’s t test was used for comparison of continuous variables. Fisher’s exact test was used for analysis of nominal variable. A P value ≤0.05 was considered to be statistically significant.ResultsDifferences existed between two groups in tumor size ((7.2 ± 3.3)cm in MPNST vs. (3.8 ± 1.4)cm in BPNST), unclear margin (4/6 in MPNST vs. 1/28 in BPNST), eccentricity to the nerve (1/6 in MPNST vs. 21/28 in BPNST), intratumoral lobulation (4/6 in MPNST vs. 2/28 in BPNST), peritumoral edema (3/6 in MPNST vs. 0 in BPNST), and peripheral enhancement (4/6 in MPNST (three of five MR, one CT) vs. 4/28 in BPNST). Bone destruction was observed in one MPNST.ConclusionsMR imaging is a valuable, non-invasive modality for the diagnosis of MPNST. Peripheral enhancement with non-cystic appearance or remarkable heterogeneous enhancement may be useful for differential diagnosis. Other imaging features such as large size (over 5 cm in diameter), ill-defined margin, intratumoral lobulation, peritumoral edema, and adjacent bone destruction are also supportive of MPNST.

【 授权许可】

CC BY   
© Yu et al. 2016