A feasibility evaluation of x-ray fluorescence emission tomography and x-ray luminescence tomography for real-time assessment of photodynamic therapy

X-ray;fluorescence;luminescence;Computed;Tomography;nanoparticles

George, Jonathan ; Meng ; Ling-Jian

关键词: X-ray;    fluorescence;    luminescence;    Computed;    Tomography;    nanoparticles;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/92662/GEORGE-THESIS-2016.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Photodynamic Therapy (PDT) has found use in a wide-array of clinical applications such as incancer and acne treatment. Photodynamic therapy, uses a photosensitive compound activated by aspecific wavelength photon to produce cytotoxic oxygen species (either in free radical form or insinglet form). However, weak penetration of visible, infrared, and UV light into the body toactivate the photosensitive compound significantly limits the use of PDT in cancer treatment.Additionally, PDT current lacks an effective dosimetry technique or means of quantifying thenumber of activated photosensitizers for investigative studies has proven difficult as well. Manyresearchers have delved into investigating x-ray induced PDT, which in combination of x-rayfluorescence computed tomography (XFCT), can produce a quantifiable therapeutic effect atgreater bodily depths. This work demonstrates a novel combinatorial system of X-ray Fluorescenceand X-ray Luminescence Computed Tomography (XLCT) to image LaF3 and Y2O3 nanoparticles.A 3D XFCT/CT image of a mouse phantom conjugated with a NMR tube containing bromide andY2O3 was produced. Additionally, a cross sectional imaging in XFCT/XLCT/CT of a mousephantom with microcapillaries filled with LaF3:Tb3+ and Y2O3:Eu3+ attached. The resultsdemonstrated the plausibility of using a XFCT/XLCT/CT setup for monitoring therapeuticnanoparticles, but acquisition time and penetration depth issues will need to be addressed first.