Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population

Lipids in Health and Disease

Research

FengHe Cui¹  YunFeng Li²  KeZhong Li³  XueWu Zhang⁴  ChangShan An⁵ 

[1] Clinical College of Yanbian University, 133000, Yanji, China;Department of Anesthesiology, Yantai Yuhuangding Hospital, 264000, Yantai, China;Department of Anesthesiology, Weihai Municipal Hospital, 264200, Weihai, China;Department of Anesthesiology, Yantai Yuhuangding Hospital, 264000, Yantai, China;Department of Biochemistry and Molecular Biology, Basic College of Yanbian University, 133000, Yanji, China;Department of Respiratory Medicine, Clinical College of Yanbian University, No. 1327 Juzi Street, 133000, Yanji, China;

关键词: Apolipoprotein C3;    Gene polymorphism;    Lipid;    Coronary artery disease;   

DOI  :  10.1186/1476-511X-13-170

 received in 2014-10-06, accepted in 2014-10-23,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe disorder of triglyceride (TG) metabolism leading to hypertriglyceridemia is an independent risk factor for coronary artery disease (CAD). Variants in the apolipoprotein C3 (APOC3) gene were found to be associated with elevated TG levels. The purpose of this study was to investigate the effect of two polymorphisms (1100 C/T and 3238 C/G) of APOC3 on plasma lipid and risk of CAD in a Chinese population.MethodsThe study population consisted of 600 patients with CAD and 600 age- and gender-matched controls. The APOC3 gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsPatients with CAD had a significantly higher frequency of APOC3 3238 GG genotype [odds ratio (OR) =1.64, 95% confidence interval (CI) =1.10, 2.43; P = 0.01] and APOC3 3238 G allele (OR =1.27, 95% CI =1.04, 1.55; P = 0.02) than controls. The findings are still emphatic by the Bonferroni correction. When stratifying by hyperlipidemia, CAD patients with hyperlipidemia had a significantly higher frequency of APOC3 3238 GG genotype (OR =1.73, 95% CI =1.13, 2.64; P = 0.01) than without hyperlipidemia. The APOC3 3238 G allele was significantly associated with increasing plasma TG levels and very-low-density lipoprotein cholesterol (VLDL-C) levels both in cases and controls (P < 0.001).ConclusionsThe APOC3 3238 G allele might contribute to an increased risk of CAD as a result of its effect on TG and VLDL-C metabolism.

【 授权许可】

Unknown   
© Cui et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.