Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Lipids in Health and Disease

Research

Kanae Karita¹  Naomi Matsunaga¹  Masao Yoshida¹  Yutaka Takashima¹  Mamoru Ishikawa²  Tadahiro Ohtsu³  Takako Shirasawa³  Naoki Shimada³  Hirotaka Ochiai³  Taku Ito³  Hiromi Hoshino³  Teruyoshi Kawamoto³  Akatsuki Kokaze⁴ 

[1] Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;Mito Red Cross Hospital, 3-12-48 Sannomaru, 310-0011, Mito-shi, Ibaraki, Japan;Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, 142-8555, Shinagawa-ku, Tokyo, Japan;Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, 142-8555, Shinagawa-ku, Tokyo, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka-shi, Tokyo, Japan;

关键词: Alcohol Consumption;    Cholesteryl Ester Transfer Protein;    Coffee Consumption;    Daily Drinker;    Daily Alcohol Consumption;   

DOI  :  10.1186/1476-511X-10-105

 received in 2011-05-20, accepted in 2011-06-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCombined effects between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol consumption on the risk of hypertension or hyperuricemia have been reported. The objective of this study was to investigate whether Mt5178 C/A polymorphism modulates the effects of alcohol consumption on the risk of dyslipidemia.MethodsA total of 394 male subjects were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effect of Mt5178 polymorphism and alcohol consumption on the risk of dyslipidemia was conducted.ResultsFor men with Mt5178C, alcohol consumption was significantly and negatively associated with the risk of hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol ≥ 140 mg/dl) (P for trend = 0.015). After adjustment for age, body mass index (BMI), habitual smoking, coffee consumption and use of antihypertensive medicine, the odds ratio (OR) for hyper-LDL cholesterolemia was significantly lower in daily drinkers with Mt5178C than non-drinkers with Mt5178C (OR = 0.360, 95% confidence intervals: 0.153-0.847). A significant and negative association between alcohol consumption and serum LDL cholesterol levels was also observed in Mt5178C genotypic men (P for trend < 0.01). On the other hand, the association between Mt5178A genotype and risk of hyper-LDL cholesterolemia does not appear to depend on alcohol consumption.ConclusionsFor Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia.

【 授权许可】

Unknown   
© Kawamoto et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.