Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial

Nutrition Journal

Research

Nicole M Wedick¹  Qi Sun²  Frank B Hu³  Rob M van Dam³  Aoife M Brennan⁴  Christos S Mantzoros⁵ 

[1]Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

[2]Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

[3]Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA

[4]Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

[5]Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

[6]Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA

[7]Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

[8]Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

[9]Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA

[10]Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA

关键词: Caffeinated;    Chlorogenic Acid;    Adiponectin Level;    Coffee Consumption;    Caffeine Concentration;   

DOI  :  10.1186/1475-2891-10-93

 received in 2011-05-01, accepted in 2011-09-13,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCoffee consumption has been associated with a lower risk of type 2 diabetes in prospective cohort studies, but the underlying mechanisms remain unclear. The aim of this study was to evaluate the effects of regular and decaffeinated coffee on biological risk factors for type 2 diabetes.MethodsRandomized parallel-arm intervention conducted in 45 healthy overweight volunteers who were nonsmokers and regular coffee consumers. Participants were assigned to consumption of 5 cups (177 mL each) per day of instant caffeinated coffee, decaffeinated coffee, or no coffee (i.e., water) for 8 weeks.ResultsAverage age was 40 years and body mass index was 29.5 kg/m2. Compared with consuming no coffee, consumption of caffeinated coffee increased adiponectin (difference in change from baseline 1.4 μg/mL; 95% CI: 0.2, 2.7) and interleukin-6 (difference: 60%; 95% CI: 8, 138) concentrations and consumption of decaffeinated coffee decreased fetuin-A concentrations (difference: -20%; 95% CI: -35, -1). For measures of glucose tolerance, insulin sensitivity, and insulin secretion, no significant differences were found between treatment groups.ConclusionsAlthough no changes in glycemia and/or insulin sensitivity were observed after 8 weeks of coffee consumption, improvements in adipocyte and liver function as indicated by changes in adiponectin and fetuin-A concentrations may contribute to beneficial metabolic effects of long-term coffee consumption.Trial Registrationclinicaltrials.gov NCT00305097

【 授权许可】

CC BY   
© Wedick et al; licensee BioMed Central Ltd. 2011