Stabilizing the immune system by chlorogenic acid

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Julia Kzhyshkowska¹ 

[1] Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University;German Red Cross Blood Service Baden-Württemberg-Hessen

关键词: Chlorogenic Acid;    macrophage;    pneumonia;    sirtuin;    sodium-glucose cotransporter;   

DOI  :  10.1002/JLB.3CE0821-427RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

It has been suggested that CGA can control glucose, amino acid, andlipid metabolism1,2. In a mouse model of DSS-induced ulcerative colitis,CGA reduced mucosal damage, suppressed inflammation and oxidativestress, and reduced expression of components of the MAPK/ERK/JNKsignaling pathways.3 Human macrophages respond to the CGA fromthe Nelumbo nucifera (Indian lotus) extract by the suppression of NFκB-dependent inflammatory response and by the decreased production of TNFalpha.2 In human endothelial cells, CGA enhanced sirtuin 1(SIRT1) deacetylase activity and reversed oxLDL-impaired SIRT1 activity, mitigated oxLDL-induced oxidative stress and dysfunction of mitochondrial biogenesis.4 Silencing SIRT1, AMPK, and PGC-1 diminishedthe ability of CGA to protect cells against oxidative stress, indicatingthat CGA inhibits oxLDL-induced endothelial apoptosis through modulating SIRT1 and AMPK/PGC-1 function in the vasculature.

【 授权许可】

CC BY