Phosphorylation of P68 RNA Helicase by P38 MAP kinase contributes to colon cancer cells apoptosis induced by oxaliplatin

BMC Cell Biology

Research Article

Heena Dey¹  Zhi-Ren Liu¹ 

[1] Department of Biology, Georgia State University, 30303, Atlanta, GA, USA;

关键词: P68 RNA helicase;    Oxaliplatin;    Phosphorylation;    p38 MAP kinase;    DEAD-box;    Apoptosis;   

DOI  :  10.1186/1471-2121-13-27

 received in 2012-06-28, accepted in 2012-10-15,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundWe previously demonstrated that p68 phosphorylation at threonine residues correlates with cancer cell apoptosis under the treatments of TNF-α and TRAIL (Yang, L. Mol Cancer Res Vol 3, pp 355–63 2005).ResultsIn this report, we characterized the role of p68 phosphorylation in apoptosis induction under the treatment of oxaliplatin in the colon cancer cells. Our data suggest that oxaliplatin treatment activates p38 MAP kinase, which subsequently phosphorylates p68 at T564 and/or T446. The phosphorylation of p68, at least partially, mediates the effects of the drug on apoptosis induction, as mutations at these two sites greatly reduce the cancer cell death.ConclusionOur studies reveal an important molecular mechanism that mediates the effects of anti-cancer drug, providing a potential strategy for improving cancer treatment.

【 授权许可】

CC BY   
© Dey and Liu; licensee BioMed Central Ltd. 2012