Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies

BMC Medicine

Research Article

Jae H. Kang¹  Charles S. Fuchs²  Frank B. Hu³  Walter C. Willett⁴  Eric B. Rimm⁴  Louis R. Pasquale⁵  Tao Huang⁶  Lu Qi⁷  Tiange Wang⁸  Majken K. Jensen⁹  Yan Zheng⁹  Hannia Campos^1,10  Janey L. Wiggs^1,11 

[1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA;Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 70112, New Orleans, LA, USA;Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 70112, New Orleans, LA, USA;Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 70112, New Orleans, LA, USA;Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Center for Research and Innovation in Translational Nutrition and Health (CIINT), Universidad Hispanoamericana, San Jose, Costa Rica;Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA;

关键词: Gene-diet interaction;    Coffee;    Genetic predisposition;    Body mass index;    Obesity;   

DOI  :  10.1186/s12916-017-0862-0

 received in 2017-02-12, accepted in 2017-04-25,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWhether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown.MethodsWe analyzed the interactions between genetic predisposition and habitual coffee consumption in relation to BMI and obesity risk in 5116 men from the Health Professionals Follow-up Study (HPFS), in 9841 women from the Nurses’ Health Study (NHS), and in 5648 women from the Women’s Health Initiative (WHI). The genetic risk score was calculated based on 77 BMI-associated loci. Coffee consumption was examined prospectively in relation to BMI.ResultsThe genetic association with BMI was attenuated among participants with higher consumption of coffee than among those with lower consumption in the HPFS (Pinteraction = 0.023) and NHS (Pinteraction = 0.039); similar results were replicated in the WHI (Pinteraction = 0.044). In the combined data of all cohorts, differences in BMI per increment of 10-risk allele were 1.38 (standard error (SE), 0.28), 1.02 (SE, 0.10), and 0.95 (SE, 0.12) kg/m2 for coffee consumption of < 1, 1–3 and > 3 cup(s)/day, respectively (Pinteraction < 0.001). Such interaction was partly due to slightly higher BMI with higher coffee consumption among participants at lower genetic risk and slightly lower BMI with higher coffee consumption among those at higher genetic risk. Each increment of 10-risk allele was associated with 78% (95% confidence interval (CI), 59–99%), 48% (95% CI, 36–62%), and 43% (95% CI, 28–59%) increased risk for obesity across these subgroups of coffee consumption (Pinteraction = 0.008). From another perspective, differences in BMI per increment of 1 cup/day coffee consumption were 0.02 (SE, 0.09), –0.02 (SE, 0.04), and –0.14 (SE, 0.04) kg/m2 across tertiles of the genetic risk score.ConclusionsHigher coffee consumption might attenuate the genetic associations with BMI and obesity risk, and individuals with greater genetic predisposition to obesity appeared to have lower BMI associated with higher coffee consumption.

【 授权许可】

CC BY   
© The Author(s). 2017