Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

Nutrition Journal

Research

Jytte Halkjær¹  Anne Tjønneland¹  Lars Ängquist²  Thorkild I. A. Sørensen³  Janne S. Tolstrup⁴  Lise Lotte N. Husemoen⁵  Ulla Toft⁵  Allan Linneberg⁶  Jeanett F Rohde⁷  Sofus C. Larsen⁷  Berit L Heitmann⁸  Kim Overvad⁹  Oluf Pedersen^1,10  Torben Hansen^1,10 

[1] Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark;Department of Clinical Epidemiology (Formerly ‘Institute of Preventive Medicine’), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark;Department of Clinical Epidemiology (Formerly ‘Institute of Preventive Medicine’), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark;The Novo Nordisk Foundation Center for Basic Metabolic Research (Section of Metabolic Genetics), and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark;MRC Integrative Epidemiology Unit, Bristol University, Senate House, Tyndall Avenue, BS8 1TH, Bristol, UK;National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5 A, 1353, Copenhagen K, Denmark;Research Centre for Prevention and Health, Capital Region of Denmark, Nordre Ringvej 57, building 84-85, 2600, Glostrup, Denmark;Research Centre for Prevention and Health, Capital Region of Denmark, Nordre Ringvej 57, building 84-85, 2600, Glostrup, Denmark;Department of Clinical Experimental Research, Rigshospitalet, Nordre Ringvej 57, 2600, Glostrup, Denmark;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, København N, Denmark;Research Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark;Department of Clinical Epidemiology (Formerly ‘Institute of Preventive Medicine’), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark;Research Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark;Department of Clinical Epidemiology (Formerly ‘Institute of Preventive Medicine’), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark;National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5 A, 1353, Copenhagen K, Denmark;The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, The University of Sydney, 2006, Sydney, NSW, Australia;Section for General Practice, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, entrance Q, 1014, Copenhagen K, Denmark;Section for Epidemiology, Department of Public Health, Aarhus University, Nordre Ringgade 1, 8000, Aarhus C, Denmark;Department of Cardiology, Aalborg University Hospital, Fredrik Bajers Vej 7-D3, 9220, Aalborg, Denmark;The Novo Nordisk Foundation Center for Basic Metabolic Research (Section of Metabolic Genetics), and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark;

关键词: Alcohol;    Weight change;    Waist change;    Genetic predisposition;    SNP score;    Gene-diet interaction;   

DOI  :  10.1186/s12937-017-0274-1

 received in 2016-10-12, accepted in 2017-08-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundStudies have suggested a link between alcohol intake and adiposity. However, results from longitudinal studies have been inconsistent, and a possible interaction with genetic predisposition to adiposity measures has often not been taken into account.ObjectiveTo examine the association between alcohol intake recorded at baseline and subsequent annual changes in body weight (∆BW), waist circumference (ΔWC) and WC adjusted for BMI (ΔWCBMI), and to test for interaction with genetic predisposition scores based on single nucleotide polymorphisms (SNPs) associated with various forms of adiposity.MethodThis study included a total of 7028 adult men and women from MONICA, the Diet, Cancer and Health cohort (DCH), and the Inter99 studies. We combined 50 adiposity-associated SNPs into four scores indicating genetic predisposition to BMI, WC, WHRBMI and all three traits combined. Linear regression was used to examine the association of alcohol intake (drinks of 12 g (g) alcohol/day) with ΔBW, ΔWC, and ΔWCBMI, and to examine possible interactions with SNP-scores. Results from the analyses of the individual cohorts were combined in meta-analyses.ResultsEach additional drink/day was associated with a ΔBW/year of −18.0 g (95% confidence interval (CI): −33.4, −2.6, P = 0.02) and a ΔWC of −0.3 mm/year (−0.5, −0.0, P = 0.03). In analyses of women only, alcohol intake was associated with a higher ΔWCBMI of 0.5 mm/year (0.2, 0.9, P = 0.002) per drink/day. Overall, we found no statistically significant interactions between the four SNP-scores and alcohol intake in relation to changes in adiposity measures. However in analyses of women separately, we found interaction between the complete score of all 50 SNPs and alcohol intake in relation to ΔBW (P for interaction = 0.03). No significant interaction was observed among the men.ConclusionAlcohol intake was associated with a decrease in BW and WC among men and women, and an increase in WCBMI among women only. We found no strong indication that these associations depend on a genetic predisposition to adiposity.Trial registrationRegistry: ClinicalTrials.gov Trial number: CT00289237, Registered: 19 September 2005 retrospectively registered.

【 授权许可】

CC BY   
© The Author(s). 2017