Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts

Nutrition Journal

Thorkild IA Sørensen²  Berit L Heitmann³  Ulla Toft¹  Lise Lotte N Husemoen¹  Allan Linneberg¹  Torben Hansen²  Oluf Pedersen²  Kim Overvad⁴  Jytte Halkjær⁶  Anne Tjønneland⁶  Nina Roswall⁶  Tea Skaaby¹  Tarunveer Singh Ahluwalia⁷  Lars Ängquist⁵  Sofus C Larsen⁵ 

[1] Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark;The Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, The University of Sydney, Sydney, Australia;Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark;Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, ground floor, 2000, Frederiksberg Copenhagen, Denmark;Danish Cancer Society Research Center, Copenhagen, Denmark;Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

关键词: Weight change;    Gene-diet interaction;    Genetic predisposition;    Ascorbic acid;   

Others  :  801459
DOI  :  10.1186/1475-2891-13-43

 received in 2014-01-20, accepted in 2014-04-29,  发布年份 2014

【 摘 要 】

Background

Cross-sectional data suggests that a low level of plasma ascorbic acid positively associates with both Body Mass Index (BMI) and Waist Circumference (WC). This leads to questions about a possible relationship between dietary intake of ascorbic acid and subsequent changes in anthropometry, and whether such associations may depend on genetic predisposition to obesity. Hence, we examined whether dietary ascorbic acid, possibly in interaction with the genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHR), associates with subsequent annual changes in weight (∆BW) and waist circumference (∆WC).

Methods

A total of 7,569 participants’ from MONICA, the Diet Cancer and Health study and the INTER99 study were included in the study. We combined 50 obesity associated single nucleotide polymorphisms (SNPs) in four genetic scores: a score of all SNPs and a score for each of the traits (BMI, WC and WHR) with which the SNPs associate. Linear regression was used to examine the association between ascorbic acid intake and ΔBW or ΔWC. SNP-score × ascorbic acid interactions were examined by adding product terms to the models.

Results

We found no significant associations between dietary ascorbic acid and ∆BW or ∆WC. Regarding SNP-score × ascorbic acid interactions, each additional risk allele of the 14 WHR associated SNPs associated with a ∆WC of 0.039 cm/year (P = 0.02, 95% CI: 0.005 to 0.073) per 100 mg/day higher ascorbic acid intake. However, the association to ∆WC only remained borderline significant after adjustment for ∆BW.

Conclusion

In general, our study does not support an association between dietary ascorbic acid and ∆BW or ∆WC, but a diet with a high content of ascorbic acid may be weakly associated to higher WC gain among people who are genetically predisposed to a high WHR. However, given the quite limited association any public health relevance is questionable.

【 授权许可】

   
2014 Larsen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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